Protein Info for BWI76_RS18395 in Klebsiella michiganensis M5al

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 555 transmembrane" amino acids 13 to 36 (24 residues), see Phobius details amino acids 350 to 373 (24 residues), see Phobius details PF17151: CHASE7" amino acids 35 to 220 (186 residues), 243.5 bits, see alignment E=1.3e-76 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 387 to 552 (166 residues), 174 bits, see alignment E=1.1e-55 PF00990: GGDEF" amino acids 391 to 550 (160 residues), 144.2 bits, see alignment E=3.1e-46

Best Hits

KEGG orthology group: None (inferred from 70% identity to eae:EAE_23085)

Predicted SEED Role

"FIG00732790: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (555 amino acids)

>BWI76_RS18395 diguanylate cyclase (Klebsiella michiganensis M5al)
MDKLMWVEKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVAHE
FDSLLQFNIDRMIFFRNGMRSALGTPLDFAALRKAEEDYLTKRHDPIWSVEIHNRRTLPI
YGVADAFVDSDALLSRDNPFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRSGFFTTT
ELPKNSTQALALYSRATGAAWFTRQTQRNNPARGIVWQTFPDDESQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNRLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIQEGVRGDFGSITIALMLMWL
MFTLMLLISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERAIAETRLSERLK
RPVAVIQLDLDYFKSVNDRFGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TPLKEAQVIAERIRIRINSREILLGNSISLRITASLGVSGSDDTGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG