Protein Info for BWI76_RS18325 in Klebsiella michiganensis M5al

Annotation: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00560: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
  • amino acids 3 to 180 (178 residues), 210.6 bits, E=1.3e-66
• PF01066: CDP-OH_P_transf
  • amino acids 3 to 166 (164 residues), 131.4 bits, E=1.9e-42

Best Hits

Swiss-Prot: 91% identical to PGSA_ECOL5: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (pgsA) from Escherichia coli O6:K15:H31 (strain 536 / UPEC)

KEGG orthology group: K00995, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [EC: 2.7.8.5] (inferred from 93% identity to ent:Ent638_2499)

MetaCyc: 91% identical to CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (Escherichia coli K-12 substr. MG1655)
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [EC: 2.7.8.5]

Predicted SEED Role

"CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.5)

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (11/12 steps found)
• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• cardiolipin biosynthesis I (3/3 steps found)
• cardiolipin biosynthesis II (3/3 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (10/13 steps found)
• cardiolipin biosynthesis III (2/3 steps found)
• type I lipoteichoic acid biosynthesis (S. aureus) (5/17 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.5

Sequence Analysis Tools

See A0A285B686 at UniProt or InterPro

Protein Sequence (182 amino acids)

>BWI76_RS18325 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (Klebsiella michiganensis M5al)
MQFNIPTLLTLFRVILIPFFVLAFYLPFTWAPFACALIFFVAAVTDWFDGYLARRWNQST
RFGAFLDPVADKVMVAIAMVLVAEHYHTWWVTLPAATMIAREIIISALREWMAELGKRSS
VAVSWIGKVKTTAQMAALVWMLWRPNIWVEWAGIGLFLVAAVLTLWSMLQYLNAARGDLL
DQ