Protein Info for BWI76_RS18200 in Klebsiella michiganensis M5al

Annotation: copper homeostasis protein CutC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 244 PF03932: CutC" amino acids 3 to 200 (198 residues), 268 bits, see alignment E=2.2e-84

Best Hits

Swiss-Prot: 80% identical to CUTC_KLEP3: Copper homeostasis protein CutC (cutC) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: None (inferred from 84% identity to eae:EAE_22905)

Predicted SEED Role

"Cytoplasmic copper homeostasis protein cutC" in subsystem Copper homeostasis: copper tolerance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B5M6 at UniProt or InterPro

Protein Sequence (244 amino acids)

>BWI76_RS18200 copper homeostasis protein CutC (Klebsiella michiganensis M5al)
MTLLEVCCYSMECALEAQRRGADRIELCAAPQEGGLTPSLGVLKSVREAVTIPVHPIIRP
RGGDFCYTAGEFAAMLDDVAAVKDLGFPGLVIGILDADGRVDRARMKKIMAAAGTLAVTF
HRAFDMCANPRQASVELAELGVQRILTSGQQASAEKGISLIRELISQSDTPIIMAGAGVR
AANLPLFLQAGVKEVHTSAGQWLPSPMRFRNPGLSMSTDAEADEYLRYAVNGEAVAEMKK
IITA