Protein Info for BWI76_RS18070 in Klebsiella michiganensis M5al

Annotation: DNA polymerase III subunit epsilon

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 219 PF00929: RNase_T" amino acids 4 to 147 (144 residues), 56.4 bits, see alignment E=5.7e-19 PF20600: ExoX-like_C" amino acids 174 to 203 (30 residues), 51.1 bits, see alignment 6.8e-18

Best Hits

Swiss-Prot: 87% identical to EXOX_ECOL6: Exodeoxyribonuclease 10 (exoX) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K10857, exodeoxyribonuclease X [EC: 3.1.11.-] (inferred from 93% identity to kpu:KP1_3488)

Predicted SEED Role

"Exodeoxyribonuclease X (EC 3.1.11.-)" (EC 3.1.11.-)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.-

Use Curated BLAST to search for 3.1.11.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B5U4 at UniProt or InterPro

Protein Sequence (219 amino acids)

>BWI76_RS18070 DNA polymerase III subunit epsilon (Klebsiella michiganensis M5al)
MLRVIDTETCGLQGGIVEIASVDIIDGQITNPMSHLVRPDRPISPQAMAIHRITEEMVAD
KPWIEEIVPLYMGSPWYVAHNASFDRRVLPEMQGEWICTMKLARRLWPGIKYSNMGLYKS
RKLSVATPPGLHHHRALYDCYITAALLLDIINTSGWTPEEMATITGRPALLSTFTFGKYR
GKPVSEVAENDPGYLRWLFNNLDRMSPELRLTLKHYLGE