Protein Info for BWI76_RS17975 in Klebsiella michiganensis M5al

Annotation: tail-specific protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 682 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF17804: TSP_NTD" amino acids 49 to 232 (184 residues), 202 bits, see alignment E=2.2e-63 TIGR00225: C-terminal processing peptidase" amino acids 194 to 551 (358 residues), 420.6 bits, see alignment E=2e-130 PF00595: PDZ" amino acids 241 to 320 (80 residues), 44.9 bits, see alignment E=2.5e-15 PF03572: Peptidase_S41" amino acids 356 to 528 (173 residues), 167.1 bits, see alignment E=5.3e-53 PF11818: DUF3340" amino acids 536 to 667 (132 residues), 140.8 bits, see alignment E=8.4e-45

Best Hits

Swiss-Prot: 91% identical to PRC_SALTY: Tail-specific protease (prc) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: None (inferred from 94% identity to eae:EAE_22675)

MetaCyc: 90% identical to tail-specific protease (Escherichia coli K-12 substr. MG1655)
C-terminal processing peptidase. [EC: 3.4.21.102]

Predicted SEED Role

"Tail-specific protease precursor (EC 3.4.21.102)" (EC 3.4.21.102)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.102

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B5R7 at UniProt or InterPro

Protein Sequence (682 amino acids)

>BWI76_RS17975 tail-specific protease (Klebsiella michiganensis M5al)
MNKFFKLTALAGLLVIAGQSFAVDDITRIDQIPVLKEEPQHATVSERVTSRFTRSHYRQF
DLDNAFSAKIFDRYLNLLDYSHNVLLASDVAQFAAKKNQIGDELRSGKLDVFYDLYNLAQ
KRRFERYQYALKVLERPMDFAGNDNFNLDRSKSPWPKDEAELNALWDAKVKFDQLSLKLA
GKDDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTE
MSLSLEGIGAVLQMDDDYTVINSLVAGGPAAKSKAISVGDRIVGVGQPGKGMVDVIGWRL
DDVVALIKGPKGSKVRLEILPAGKGAKTRIVTLTRERIRLEDRAVKMTVKTVGKEKVGVL
DIPGFYVGLTDDVKVQLQKLEKQNVSSIVIDLRSNGGGALTEAVSLSGLFIPSGPVVQVR
DNNGKVREDSDTDGVVYYKGPLVVLVDRFSASASEIFAAAMQDYGRALIVGEPTFGKGTV
QQYRSLNRIYDQMLRPDWPALGSVQYTIQKFYRINGGSTQRKGVTPDIMMPTGTEERETG
EQYEDNALPWDSVNAATYVKYGDLTPFGPELLKRHDARIAKDPEFQYIMKDIARYNAMKD
KRNIVSLNYAQREKENEEDDAIRLARVNDRLKREGKPLLKKLEDLPKDYQEPDPYLDETV
HIALDLAHEEKDRPAVEPPASK