Protein Info for BWI76_RS17870 in Klebsiella michiganensis M5al
Annotation: coenzyme A pyrophosphatase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 95% identical to NUDL_KLEP7: Uncharacterized Nudix hydrolase NudL (nudL) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
KEGG orthology group: None (inferred from 94% identity to kva:Kvar_1853)MetaCyc: 84% identical to putative NUDIX hydrolase with low 3-phosphohydroxypyruvate phosphatase activity (Escherichia coli K-12 substr. MG1655)
RXN0-6562
Predicted SEED Role
"Hypothetical nudix hydrolase YeaB" in subsystem Nudix proteins (nucleoside triphosphate hydrolases)
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285B5K6 at UniProt or InterPro
Protein Sequence (192 amino acids)
>BWI76_RS17870 coenzyme A pyrophosphatase (Klebsiella michiganensis M5al) MADSALELDDFLSRFQLLRPQPTRHALNQRQAAVLVPIVRRPQPGLLLTQRSPLMRKHAG QVAFPGGAVDNSDATLIAAALREAHEEVAIPPESVEVIGVLPPVDSVTGFQVTPVVGIIP PDLHYHASQDEVAAVFEMPLAEALRLGRYHPLDIHRRGNSHRVWLSWYQHYFVWGMTAGI IRELALQIGSRP