Protein Info for BWI76_RS17335 in Klebsiella michiganensis M5al

Annotation: nitrate reductase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1247 TIGR01580: nitrate reductase, alpha subunit" amino acids 2 to 1235 (1234 residues), 2548.2 bits, see alignment E=0 PF14710: Nitr_red_alph_N" amino acids 3 to 40 (38 residues), 62.6 bits, see alignment (E = 5e-21) PF00384: Molybdopterin" amino acids 108 to 833 (726 residues), 247.6 bits, see alignment E=3e-77 PF01568: Molydop_binding" amino acids 1087 to 1202 (116 residues), 75 bits, see alignment E=7.2e-25

Best Hits

Swiss-Prot: 94% identical to NARG_ECOLI: Respiratory nitrate reductase 1 alpha chain (narG) from Escherichia coli (strain K12)

KEGG orthology group: K00370, nitrate reductase 1, alpha subunit [EC: 1.7.99.4] (inferred from 74% identity to abo:ABO_0546)

MetaCyc: 78% identical to nitrate reductase Z subunit alpha (Escherichia coli K-12 substr. MG1655)
1.97.1.-; RXN0-3501 [EC: 1.7.5.1]

Predicted SEED Role

"Respiratory nitrate reductase alpha chain (EC 1.7.99.4)" in subsystem Nitrate and nitrite ammonification (EC 1.7.99.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.7.99.4

Use Curated BLAST to search for 1.7.5.1 or 1.7.99.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B5H7 at UniProt or InterPro

Protein Sequence (1247 amino acids)

>BWI76_RS17335 nitrate reductase subunit alpha (Klebsiella michiganensis M5al)
MSKFLDRFRYFKQKGETFADGHGQLLKTNRDWEDGYRQRWQHDKVVRSTHGVNCTGSCSW
KIYVKNGLVTWETQQTDYPRTRPDMPNHEPRGCPRGASYSWYLYSANRLKYPLMRKRLMK
MWREAKAQHSDPVDAWASIIEDADKAKSFKQARGRGGFVRSSWQEVNELIAASNVYTVKN
YGPDRVAGFSPIPAMSMVSYASGARYLSLIGGTCLSFYDWYCDLPPASPQTWGEQTDVPE
SADWYNSSYIIAWGSNVPQTRTPDAHFFTEVRYKGTKTVAITPDYAEIAKLCDLWLAPKQ
GTDAAMALAMGHVMLREFHLDKPSQYFTDYVRRYTDMPMLVMLEERDGYYAAGRMLRAAD
LVDALGQETNPEWKTVAFDEKGEITVPNGSIGFRWGDKGKWNLEQRDGKTGEDVELRLSL
LGSHDDIANVGFPYFGGEGTEHFNKVELENVLLHKLPVKRLQKADGSGVLVATVYDLTMA
NYGLDRGLGDENCASSYDDVKAYTPAWAEKITGVSRAHIIRTAREFADNADKTHGRSMII
VGAGLNHWFHLDMNYRGLINMLIFCGCVGQSGGGWAHYVGQEKLRPQTGWQPLAFALDWQ
RPARHMNSTSYFYNHSSQWRYETVTAQELLSPLADKSRYSGHLIDFNVRAERMGWLPSAP
QLGTNPLRIAQEAKKAGMTPVDYTVKSLKEGSIRFAAEQPENGKNHPRNLFIWRSNLLGS
SGKGHEYMLKYLLGTENGIQGKDLGKQGGVKPEEVEWKDNGLDGKLDLVVTLDFRLSSTC
LYSDIVLPTATWYEKDDMNTSDMHPFIHPLSAAVDPAWESKSDWDIYKDIAKKFSEVCVG
HLGKETDVVTLPIQHDSAAELAQPLDVKDWKKGECELIPGKTAPHILTVERDYPATYERF
TSIGPLMEKIGNGGKGIAWNTQSEMDLLRKLNYTKADGPAKGQPMLNTAIDAAEMVLTLA
PETNGHVAVKAWAALSEFTGRDHTHLAKNKEEEKIRFRDIQAQPRKIISSPTWSGLEDEH
VSYNAGYTNVHELIPWRTLSGRQQLYQDHQWMRDFGESLLVYRPPIDTRSVKAVMGKKSN
GNPEKALNFLTPHQKWGIHSTYSDNLLMLTLSRGGPIVWMSEADAKDLGIEDNDWIEVFN
SNGALTARAVVSQRVPAGMTMMYHAQERIVNLPGSEVTEQRGGIHNSVTRITPKPTHMIG
GYAQLAYGFNYYGTVGSNRDEFVVVRKMKNINWLDGEGNDQVQESVK