Protein Info for BWI76_RS17275 in Klebsiella michiganensis M5al

Annotation: two-component system response regulator RssB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 337 PF00072: Response_reg" amino acids 10 to 120 (111 residues), 102.7 bits, see alignment E=6.8e-34

Best Hits

Swiss-Prot: 81% identical to RSSB_ECO57: Regulator of RpoS (rssB) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 92% identity to eae:EAE_16875)

Predicted SEED Role

"Hnr protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B5H2 at UniProt or InterPro

Protein Sequence (337 amino acids)

>BWI76_RS17275 two-component system response regulator RssB (Klebsiella michiganensis M5al)
MTQPLAGKQILIVEDEPVFRSLMHTWLASLGATIVQAEDGVDALQKMAESKPDLMICDIS
MPRMNGLQLVEHVRNQGEQLPILMISATENMADIAKALCLGVQDILLKPVKDFDRLRETV
YACLYPNMFNSRVEEEERLFEDWDALVSDPTAASRLLQELQPPVQQEMSRCRIHYRQLVS
ADKPGLVLDIAPLSENDLAFYCLDVTRAGDNGVLAALLLRALFNGLLQEQLAHQGQRLPE
MGSLLKQVNQLLRQANLPGQFPLLVGYYHSGLKNLILVSAGLNGTLNTGEHQIQISNGVP
LGTLGNAYLNQISQRCASWQCQIWGAGGRLRLMLTTE