Protein Info for BWI76_RS17100 in Klebsiella michiganensis M5al

Annotation: glutathione peroxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00255: GSHPx
  • amino acids 6 to 111 (106 residues), 147.3 bits, E=5.8e-48

Best Hits

Swiss-Prot: 76% identical to BTUE_ECOLI: Thioredoxin/glutathione peroxidase BtuE (btuE) from Escherichia coli (strain K12)

KEGG orthology group: K00432, glutathione peroxidase [EC: 1.11.1.9] (inferred from 91% identity to kpu:KP1_3270)

MetaCyc: 76% identical to thioredoxin/glutathione peroxidase BtuE (Escherichia coli K-12 substr. MG1655)
Glutathione peroxidase. [EC: 1.11.1.9]; RXN0-267 [EC: 1.11.1.9, 1.11.1.24]

Predicted SEED Role

"Glutathione peroxidase family protein"

MetaCyc Pathways

• reactive oxygen species degradation (4/4 steps found)
• glutathione-peroxide redox reactions (2/3 steps found)

KEGG Metabolic Maps

• Arachidonic acid metabolism
• Glutathione metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.11.1.24 or 1.11.1.9

Sequence Analysis Tools

See A0A285B5A1 at UniProt or InterPro

Protein Sequence (183 amino acids)

>BWI76_RS17100 glutathione peroxidase (Klebsiella michiganensis M5al)
MQHDILNTEVTTIDGETTTLAPWAGKVLLIVNVASKCGLTPQYEQLEALQKAFESEGFSV
LGFPCNQFLGQEPGSEEEIKTFCSTTYGVTFPMFSKIDVNGEHRAPLYQKLVDAAPQAVA
PEGSGFYERMASKGRAPLYVDDILWNFEKFLIGRDGQVIGRFSPDMTPDDPQLVAAIKGA
LAK