Protein Info for BWI76_RS16945 in Klebsiella michiganensis M5al

Annotation: 4-hydroxyphenylpyruvate dioxygenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01261: AP_endonuc_2
  • amino acids 19 to 259 (241 residues), 120.5 bits, E=2.1e-38
• PF14696: Glyoxalase_5
  • amino acids 289 to 418 (130 residues), 91.2 bits, E=1.4e-29

Best Hits

KEGG orthology group: None (inferred from 84% identity to eae:EAE_17180)

Predicted SEED Role

"4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)" in subsystem Aromatic amino acid degradation or Homogentisate pathway of aromatic compound degradation or Plastoquinone Biosynthesis or Tocopherol Biosynthesis (EC 1.13.11.27)

MetaCyc Pathways

• L-tyrosine degradation I (4/5 steps found)
• plastoquinol-9 biosynthesis I (1/3 steps found)
• L-phenylalanine degradation IV (mammalian, via side chain) (5/9 steps found)
• superpathway of plastoquinol biosynthesis (2/5 steps found)
• vitamin E biosynthesis (tocopherols) (1/7 steps found)

KEGG Metabolic Maps

• Phenylalanine metabolism
• Tyrosine metabolism
• Ubiquinone and menaquinone biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.13.11.27

Use Curated BLAST to search for 1.13.11.27

Sequence Analysis Tools

See A0A285B530 at UniProt or InterPro

Protein Sequence (617 amino acids)

>BWI76_RS16945 4-hydroxyphenylpyruvate dioxygenase (Klebsiella michiganensis M5al)
MLRSIATVSISGTLPEKLHAIAAAGYQGVEIFENDLLYYTGTPADIRHLAADLGLKITLF
QPFRDFEGASRSQFAANMERARRKFALMHELGCDTMLLCSNVQPDCSADVELQIADLRAL
AELAEQEQIRIGYEALAWGTHVNRWHQAWSRVKSVNSPALGIVLDSFHVLARGDTLQRLG
EVPPEKITFVQMADAPLMKMDILEWSRHFRCFPAQGQLPLVDFACDLTRCGYRGPWSLEI
FNDSFRASPNGATAKDGYRSLLWLEEQVRQRLPESRAPLFAPVELPLYAGLEFIEFAAAP
AQAGELGQRLAQLGFAEEGSHRSKRVSLWRNGGARVVVNAQPHSWADHFHQRHGVSLCAM
ALRVSQSAAIVERARAYGYATWQGDAGPNESPIPAVCAPDGSLIYLIEVGDDIYTRDFHL
RANLTPRDDYQGIDHLALGMEADSRDNWIIFFRSVFGFILEHEQTLPDPYGLVRSLAVRS
PQGDIRLALNISQSRATQIARSVACYQGAGLQHAAFACRDLPATLASLPQIAVEALPIPA
NYYDDLLARFGEDAQVNLLKNHQILYDCDGDGGEFLHLYTRPFSAGRFFFELTERRNGYA
LYGAVNAAVRLSAMQYT