Protein Info for BWI76_RS16470 in Klebsiella michiganensis M5al

Annotation: transcriptional repressor NemR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 199 PF00440: TetR_N" amino acids 13 to 55 (43 residues), 38 bits, see alignment 1.1e-13 PF16925: TetR_C_13" amino acids 84 to 189 (106 residues), 49.6 bits, see alignment E=4.8e-17

Best Hits

Swiss-Prot: 74% identical to NEMR_ECOLI: HTH-type transcriptional repressor NemR (nemR) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 91% identity to eae:EAE_17830)

Predicted SEED Role

"Transcriptional regulator, TetR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B4P0 at UniProt or InterPro

Protein Sequence (199 amino acids)

>BWI76_RS16470 transcriptional repressor NemR (Klebsiella michiganensis M5al)
MNKHSECNTREHILVTGEQLCMHRGFTGMGLSELLKTAEVPKGSFYHYFRSKEAFGVALL
EHHYAGYLQRLVEHFDHGQGNYRDRLLAYYQHTLTQFCQQGIISGCLTVKLSAEVCDLSE
DMRAAMDKGASQIIILLGDALEKGRQEGSLEFDDDAFTLSQVLYSLWLGANLQAKITRSA
TPLESALAHAKNIIAAPGV