Protein Info for BWI76_RS16255 in Klebsiella michiganensis M5al

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 591 PF01590: GAF" amino acids 26 to 154 (129 residues), 45.7 bits, see alignment E=1.4e-15 PF13185: GAF_2" amino acids 26 to 157 (132 residues), 46.1 bits, see alignment E=9.1e-16 PF00563: EAL" amino acids 335 to 569 (235 residues), 235.3 bits, see alignment E=9.7e-74

Best Hits

KEGG orthology group: None (inferred from 80% identity to rah:Rahaq_5173)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B4T9 at UniProt or InterPro

Protein Sequence (591 amino acids)

>BWI76_RS16255 histidine kinase (Klebsiella michiganensis M5al)
MLSDLSNDESKRRAAIDLLKNPDEGRDEALKKYTHLVCQLLKMPMSFVSVLDDEKLYIKS
AQNIAATETRLGDAFCEQTLKQGKTFICRDTHQHPVFQRDRAVREAPFIRFYAGCPLTTR
DGVAVGTLSILDTQPRELSDEQVAIFNTLAELVSDFLASWHSVGYTDVVTLLPNRQRLLK
DIEVSAVSAFRLVIIDCIDMPFAYEMARSLGMIAVENLLRDMTAQLQARLPLAGQLYAVA
VGRFAFLTPEPTALSLENIAQNLQGTQARIGPEVPLDLDIHMGDSGLCDSTLTPNEILRR
AVSALHEAISQGLRFTTYNDALDTRKKRDFSLLTELRQTLQGNQGLYLVYQPKISLATGR
VTGAEALVRWKHPTNGEVLPGEFIPLVEKTSLMRELTAWVIDRTIAQLSEWRDQGLTLPV
SINLAASDFSRPDFAEELEQKLRNASLEPALLGLECLETEKMLESPAALNGLNMLKKRGF
KISLDDFGSGYSNINYLRQMPLDIIKLDRSIVSHIVDEKASRIIVRNVIKLLKQLDYIVL
AEGVEDRKTVEILRSLGCDEVQGYFYARPMVSADFAAWSRARNAATERNPL