Protein Info for BWI76_RS16060 in Klebsiella michiganensis M5al

Annotation: LysR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 308 transmembrane" amino acids 235 to 252 (18 residues), see Phobius details PF00126: HTH_1" amino acids 11 to 66 (56 residues), 34.9 bits, see alignment E=1.2e-12 PF03466: LysR_substrate" amino acids 97 to 296 (200 residues), 121.9 bits, see alignment E=2.4e-39

Best Hits

Swiss-Prot: 93% identical to MAUR_KLEPN: Malonate utilization transcriptional regulator (mauR) from Klebsiella pneumoniae

KEGG orthology group: K13928, LysR family transcriptional regulator, malonate utilization transcriptional regulator (inferred from 95% identity to kva:Kvar_2803)

Predicted SEED Role

"Malonate utilization transcriptional regulator" in subsystem Malonate decarboxylase

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B4K6 at UniProt or InterPro

Protein Sequence (308 amino acids)

>BWI76_RS16060 LysR family transcriptional regulator (Klebsiella michiganensis M5al)
MKDDINQDITFRKLSVFMMFMAKGNIARTAEAMQLSGVSVHRALHTLEEGVGCPLFIHKG
RNLLPLPAAWTLLEYCQDVMSLMTRGLEATRKVAGVGQGRLRIGTLYSLTLETVPRIIMG
MKLRRPELELDLTMGSNQMLLDMLEDDALDAILIATNEGEFNNSAFDVVPLFEDDIFLAA
PATEQLDTTAPAELRDYARRKFVSLAEGFATYAGFQDAFQVAGFEPEIVTRVNDIFSMIS
LVQAGVGFALLPGRMKKVYENDVQLLKLAEPYQMRQLISIVYSHHRERDADLLALAAEGR
MYARSLSR