Protein Info for BWI76_RS15470 in Klebsiella michiganensis M5al

Annotation: dipeptidyl carboxypeptidase II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 680 PF01432: Peptidase_M3" amino acids 230 to 678 (449 residues), 451.6 bits, see alignment E=2.3e-139

Best Hits

Swiss-Prot: 70% identical to DCP_ECOLI: Dipeptidyl carboxypeptidase (dcp) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 84% identity to eae:EAE_18455)

MetaCyc: 70% identical to peptidyl-dipeptidase Dcp (Escherichia coli K-12 substr. MG1655)
Peptidyl-dipeptidase Dcp. [EC: 3.4.15.5]

Predicted SEED Role

"Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5)" in subsystem Protein degradation (EC 3.4.15.5)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.15.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B4L4 at UniProt or InterPro

Protein Sequence (680 amino acids)

>BWI76_RS15470 dipeptidyl carboxypeptidase II (Klebsiella michiganensis M5al)
MSENNPFFSVSLLPYQAPRFDVIDVSHYRPAFDEGVRRQRAEIAAIVNHPQPADFANTLE
ALEQSGQLLARVTNVFFAMAGAETNPTIQALDEQFSAELAELANDIWLNDALFQRVKRVW
EQRDSLSLDSESRRLLEVTWQRFTLAGAMLEDEQKAALRALNTEAAALQSQFQQRLLAAV
KSGGLVVENVHQLAGLSDEEISAAAEAAQDKGLSGRWLLPLLNTTQQPALLSLQERQTRE
NLFAAGWTRNQKGDANDTRELVLRLAEIRARKAQLLGADDFASWSMADQMAGAPGEAFAF
MRRIAPAARARAEQELADIQQVIDNEGGDFRAAAWDWLYYAEQVRRAKFAIDEAQLKPYF
ALDRVLRDGVFWTATQLFGIRFIERFDIPVYHPDVQVWEIIDANGEGIALFYGDYFSRDS
KSGGAWMGVFVEQSTLRAQHPVIYNVCNYQKPKAGHSALLSWDEVITLFHEFGHTLHGLF
ASQKYASLSGTNTPRDFVEFPSQIYEHWASEPQVFAHYARHHQTGEAMPEALRDSMFRAA
KFNKGYDMSELLAAALLDMRWHSVTVDKLPEDVDAFEAAALHAESMDLAAVPPRYRSSYF
SHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQRFREAILSRGNSTDLAELY
RQWRGHDPQIEPMLENRGLS