Protein Info for BWI76_RS15140 in Klebsiella michiganensis M5al

Annotation: CusA/CzcA family heavy metal efflux RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1037 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 339 to 357 (19 residues), see Phobius details amino acids 363 to 383 (21 residues), see Phobius details amino acids 389 to 410 (22 residues), see Phobius details amino acids 445 to 465 (21 residues), see Phobius details amino acids 484 to 504 (21 residues), see Phobius details amino acids 537 to 554 (18 residues), see Phobius details amino acids 873 to 890 (18 residues), see Phobius details amino acids 897 to 917 (21 residues), see Phobius details amino acids 923 to 947 (25 residues), see Phobius details amino acids 979 to 996 (18 residues), see Phobius details amino acids 1007 to 1031 (25 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1036 (1036 residues), 1351.2 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1032 (1027 residues), 804.7 bits, see alignment E=5.9e-246

Best Hits

Swiss-Prot: 64% identical to CUSA_ECOL6: Cation efflux system protein CusA (cusA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 66% identity to abo:ABO_1356)

MetaCyc: 65% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B492 at UniProt or InterPro

Protein Sequence (1037 amino acids)

>BWI76_RS15140 CusA/CzcA family heavy metal efflux RND transporter (Klebsiella michiganensis M5al)
MIAAVIRWSLRNRLLVLLATLIMAAWGVWSIQQAPLDALPDLSDTQVIIRVSYPGKAPQI
VEDQVTYPLTTTMLSVPGAKTVRGFSMFGDAYVYVLFEDGTDPYWARSRVLEYLSQIQSS
LPPETKASLGPDATGVGWVFEYVLTDKSGQHSLGDLRAIQDWILKYELKTVPDVSEVASV
GGMVKEYQVVLNPDRLRALNVTHQQVISAIQSANQEGGGSVLELGEAEYMVRTTGYLKSI
DDFNQVVIAARGGVPVLLSDVASVRRGPAIRRGVAELNGEGEVAGGIIIMRSGKNALTTI
DAVKAKLAEVQKSLPAGVEIVPVYDRSQLIKNSVETLTHKLIEEFIVVAVVCSLFLFHFR
SALVAMITLPLGILGAFIVMHYQGVSANMMSLGGIAIAIGAMVDAAIVMIENMHKVLEQW
RHEHPERQPSSADYWQIAQHAASEVGPALFCSLLIITLSFIPVFTLEAQEGKMFSPLAFT
KTWSMAVAAGLGITLVPVLMGYFIRGKIPDETANPLNRWLIRAYEPLLDKVLQWPKATLA
AAGLLLVATLWPLAQLGSEFLPQIDEGDLLYMPSTLPGISSREAGRLLQQTDRLIKTIPE
VQSVFGKAGRADSATDPAPLTMLETTIQFKPKSEWRPGMTMDKLISELDNTVKVPGIANV
WVPPIRNRLDMLATGIKSPVGIKVNGNNLAEIEKTAEEIERIVRNVPGVTSALAERLDGG
RYIDITIDRVKAARYGVSVKELQSIVASVVGGDNIGETIEGRERYPISVRYPRDVRDSLQ
KLRDLPVVTSGGAQVALSELADIAITDGPPMLKSENARLSDWIYVDIRGRDLKSAVDQMQ
REVSEQVKLPEGISLTWSGQYEYLERATAKLKIVLPFTLMIIFILLYVTFGQVKDALLIM
GTLPFSLVGGVWLLWLLGYNLSVAAAVGFIALAGVAAEFGVIMVLYLNQAIAKRRGRLDD
QTLNEAIHEGAVLRVRPKVMTVATIMAGLLPIMWGGGTGSEVMQRIAAPMIGGMITAPLL
SMLVIPAVYHLTHRNKR