Protein Info for BWI76_RS15070 in Klebsiella michiganensis M5al

Annotation: non-ribosomal peptide synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1456 transmembrane" amino acids 1098 to 1119 (22 residues), see Phobius details PF00668: Condensation" amino acids 27 to 456 (430 residues), 241.3 bits, see alignment E=7.3e-75 PF00501: AMP-binding" amino acids 483 to 832 (350 residues), 216.9 bits, see alignment E=1.6e-67 TIGR01733: amino acid adenylation domain" amino acids 503 to 907 (405 residues), 350.3 bits, see alignment E=1.3e-108 PF13193: AMP-binding_C" amino acids 891 to 967 (77 residues), 43.8 bits, see alignment 1.7e-14 PF00550: PP-binding" amino acids 997 to 1058 (62 residues), 49.4 bits, see alignment (E = 1.8e-16) TIGR01746: thioester reductase domain" amino acids 1099 to 1451 (353 residues), 300.1 bits, see alignment E=2.6e-93 PF01370: Epimerase" amino acids 1100 to 1309 (210 residues), 57.6 bits, see alignment E=5.4e-19 PF07993: NAD_binding_4" amino acids 1101 to 1337 (237 residues), 203.2 bits, see alignment E=1.7e-63 PF01073: 3Beta_HSD" amino acids 1101 to 1277 (177 residues), 39.9 bits, see alignment E=1e-13

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B4E7 at UniProt or InterPro

Protein Sequence (1456 amino acids)

>BWI76_RS15070 non-ribosomal peptide synthetase (Klebsiella michiganensis M5al)
MPSFNSDESNKGCLNKACGESAVTYLAATPGQQAMWWLDNTLDQPQCYNVPVLLTVNATL
DAEIMQRAVAELTLRHEIFRTRFVYLDGKLQQRIGADGYLSFSHRQPEQTETPESVTAQL
AASRLSLAEGPLSIINMLSSDSGTTWLACCFHHIIIDAPSVRIVLHDLLRIYCELDEKRA
LPAFNDTGSYQEFTRWQAASLAAAECEDMRDYWRQALHPAPPLSDLPVDFPRRLREDTKA
AYTMLALNEQEADSLQRHARSLSMTPFMYMSMCWQFFLSRMSGQNDITVGVPFTLRDRSE
FAETPGYMINTLPVRVQVNEDDTVRTLAAKVRQSFIGAHFNKLLPFNEIVALSRENAGQD
SPLFRTLLVMPDTRGDIFNDLPFKVMLDDYFSQMAKYDLTLFFEAQPQWKLTLEYKTALY
HPQTIDYWLKIFRHLLSAMGEDGEVLLSSLKLLDAPLSRELVVRSSLKPCAEAWRFDALA
AFNQHAVNHSADTALITANGTRSYGWLAERSGQIAAYLQQQFNIAPGKRVALLLERNAEA
IATLFGVLKTGAAYIPVDPQYPQERIGYMLQDAKVDCIATTRSLVARFPVSASVPLLLID
GIPPEYPGEWSYIKRMPDDELYIIYTSGSTGQPKGVRLLNKTLNNLIKWQQDVSECGQGD
CTLHFMSLSFDVSVQEIFGTLACGGRLYIASEEERRDLDHLQEVIQEQGINRLYFPYVAL
QQFAHLSALANRQFPSLKEVYSTGEQLVLTADIKHFFRQPVRLINLYGPSESHVCSAYVL
PPESDKWGDAASIGYPLPGFTLLVVDAHLQLVPAGVAGELLIVSDFLSPGYHNKSEESAR
RFISAEGFAAQSCHAYRTGDLVRLEHDDRFSYLGRLDNQLKIRGFRIEPSEVEAAINALE
GVQVSAVVGRADNSGSKQLIAFIAGLLDDKGNQKDKIKRGLRLVLPEYMVPTELVFVDKL
PTTPSGKIDRKALLKVDIIIESSTQMPERSLTKTQEQVRALWETLFPGRHIALHDDFFAI
GGHSLLATQLVFLLRKAFDCDIPLRLLFNHPTLSAMAESIDGYIASEKGPVDAVDRSFVQ
DGYERIHWQGGVRSTPGLTLLTGATGFLGIYLLRSLLLAGTQSVLCMVRARTDEHALARL
RENAMRYGIADEIDFSRVEVCLGDIGQRNLGLSSEAYSRLAERVDTVFHAAAQINFLLSY
SSVKQSNVQGTLNILAFCGCGGRKTLHYLSTIAVFSPRYPQSPIVEHCVPGHPEALSIGY
TQSKWVAERYVIQAREQGLDANVFRIGRIGGDSRSGACQSDDFLWRQIKTFIQMGLAPDP
SSLSTDLLPVDFVAEAIVALARSEATRQENFHIFHPQSTRFDPVYRAIRSLGYPLETTSD
GEWLQQLELCVTQGREVALGPVIHLFKENLLDTGDNAYGNPETTKRITQLGLRFPELSEE
TFKRMIVYFQRQNEIV