Protein Info for BWI76_RS14945 in Klebsiella michiganensis M5al

Annotation: PTS system, cellobiose-specific IIC component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 439 transmembrane" amino acids 31 to 51 (21 residues), see Phobius details amino acids 70 to 92 (23 residues), see Phobius details amino acids 104 to 121 (18 residues), see Phobius details amino acids 141 to 159 (19 residues), see Phobius details amino acids 180 to 200 (21 residues), see Phobius details amino acids 226 to 246 (21 residues), see Phobius details amino acids 287 to 307 (21 residues), see Phobius details amino acids 332 to 356 (25 residues), see Phobius details amino acids 364 to 388 (25 residues), see Phobius details amino acids 394 to 412 (19 residues), see Phobius details TIGR00359: PTS system, cellobiose-specific IIC component" amino acids 12 to 423 (412 residues), 436.6 bits, see alignment E=1.1e-134 TIGR00410: PTS system, lactose/cellobiose family IIC component" amino acids 12 to 423 (412 residues), 436.6 bits, see alignment E=1.1e-134 PF02378: PTS_EIIC" amino acids 33 to 351 (319 residues), 201.6 bits, see alignment E=8.6e-64

Best Hits

KEGG orthology group: K02761, PTS system, cellobiose-specific IIC component (inferred from 92% identity to ent:Ent638_2981)

Predicted SEED Role

"PTS system, cellobiose-specific IIC component (EC 2.7.1.69)" in subsystem Beta-Glucoside Metabolism (EC 2.7.1.69)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B458 at UniProt or InterPro

Protein Sequence (439 amino acids)

>BWI76_RS14945 PTS system, cellobiose-specific IIC component (Klebsiella michiganensis M5al)
MNNVLGFLEAKLMPLAAKTAQQRHLGAIRGAYVSFMPFIIVGSILLVISSFPNQSYQQFM
ASTFGASWSAIIEIPFNAVFSTMSLFISFLVAYRLAEHYGDDRISCGILSLVGFLILTPF
IKVAENGGITVIPVEWIGTKGLFVAMIGSLLWTELFCWLKRKKLVIKMPDGVPPAVQESF
AALIPALLVMILILAIRIGFEHTHYATIHQFIYEVVASPVRHYGTSYFGALMTVFSITIL
WSVGINSGSMINGIIRPLWMENQTDNIAAIQAGVTPPHIITEQFFDMIWMGGAGATLSLV
IAMLIFARSKNMREVARLGAGASIFNINEPILFGLPVIMNPIMLIPFNLVPLVLVTVQYA
AMKIGAVAVTTGVFIPWTLPPVISGFIVTGHLSGSVMQILNLLIGAMLYLPFMRIVDKQY
RAAEITARAETDNTLAKQE