Protein Info for BWI76_RS14535 in Klebsiella michiganensis M5al

Annotation: polyketide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 500 1000 1500 2000 2500 3158 PF00109: ketoacyl-synt" amino acids 27 to 276 (250 residues), 255 bits, see alignment E=9.4e-79 PF00108: Thiolase_N" amino acids 171 to 225 (55 residues), 27.5 bits, see alignment (E = 2.2e-09) PF02801: Ketoacyl-synt_C" amino acids 285 to 402 (118 residues), 139.1 bits, see alignment (E = 7.9e-44) PF16197: KAsynt_C_assoc" amino acids 404 to 515 (112 residues), 48.5 bits, see alignment (E = 1.2e-15) PF00698: Acyl_transf_1" amino acids 551 to 850 (300 residues), 188 bits, see alignment E=3.5e-58 PF01209: Ubie_methyltran" amino acids 1082 to 1203 (122 residues), 22 bits, see alignment (E = 1e-07) PF13489: Methyltransf_23" amino acids 1086 to 1246 (161 residues), 45.9 bits, see alignment 5.8e-15 amino acids 2584 to 2742 (159 residues), 29.2 bits, see alignment 7.7e-10 PF13847: Methyltransf_31" amino acids 1088 to 1200 (113 residues), 34 bits, see alignment (E = 2.8e-11) PF13649: Methyltransf_25" amino acids 1092 to 1192 (101 residues), 39.5 bits, see alignment (E = 8.6e-13) amino acids 2587 to 2686 (100 residues), 34.6 bits, see alignment (E = 2.8e-11) PF08241: Methyltransf_11" amino acids 1093 to 1195 (103 residues), 39 bits, see alignment (E = 1.2e-12) amino acids 2588 to 2690 (103 residues), 33.9 bits, see alignment (E = 4.4e-11) PF08242: Methyltransf_12" amino acids 1093 to 1194 (102 residues), 78.9 bits, see alignment (E = 4.6e-25) amino acids 2588 to 2688 (101 residues), 66.3 bits, see alignment (E = 3.7e-21) PF08659: KR" amino acids 1554 to 1724 (171 residues), 131.6 bits, see alignment 3.5e-41 PF00106: adh_short" amino acids 1556 to 1670 (115 residues), 27.6 bits, see alignment (E = 2.1e-09) PF00550: PP-binding" amino acids 1818 to 1883 (66 residues), 36.2 bits, see alignment (E = 6.5e-12) amino acids 2827 to 2889 (63 residues), 49.4 bits, see alignment (E = 4.9e-16) PF00668: Condensation" amino acids 1943 to 2337 (395 residues), 123.1 bits, see alignment E=1.4e-38 PF00891: Methyltransf_2" amino acids 2578 to 2694 (117 residues), 23.1 bits, see alignment (E = 4.5e-08) PF00975: Thioesterase" amino acids 2910 to 3144 (235 residues), 67.2 bits, see alignment 2.7e-21

Best Hits

Predicted SEED Role

"iron aquisition yersiniabactin synthesis enzyme (Irp1,polyketide synthetase)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (3158 amino acids)

>BWI76_RS14535 polyketide synthase (Klebsiella michiganensis M5al)
MDNLRFSSAPTADSIDASIAQRYPDCEPVAVIGYACHFPEAPDGETYWRNLLEGRECSRR
FTREALLAAGLDTAIIDDPCYVNIGTVLDNADCFDATLFGYSRQEAESIDPQQRLFLQAV
WHALEHAGYAPGAVPHKTGVFASSRMSTYPGREALNVTEVAQVKGLQSLMGNDKDYIATR
AAYKLNLHGPALSVQTACSSSLVAVHLACESLRAGESDMAVAGGVALSFPQQAGYRYQPG
MIFSPDGHCRPFDASAEGTWAGNGLGCVVLRRLKDALLSGDPIIAVILSSAVNNDGNRKV
GYTAPSVAGQQAVIEEALMLAAIDDRQIGYIETHGTGTPLGDAIEIEALRNVYAPRPPQQ
RCALGSVKSNVGHLDTAAGIAGLLKTVLAVSRGKIPPMLNFHTPNPALKLEESPFTVPVT
AQEWQDEVRYAGVSSFGIGGTNCHMIVASLPDELNISYPAADDGSKSSALLLSAASDTAL
RQLAADYAAALRENADANNLAFTALRARRLDLPFRLAAPLNHDTAAALSAWAGAKSDSPV
YSGHGASGKQVWLFTGQGSHWRTMGQSLYLHSTAFADTLERCFSACRDMLTPSLREAMFN
PDSAQLDNMAWAQPAIVAFEIAMAAHWRAEGLKADFAMGHSVGEFAAAVVCGHYTIEQVM
PLVCRRGALMQLCASGAMVAVFAQEEALMPLARQFELDLAANNGTRHTVFSGPEARIAEF
CAALSQHEIDYRRLRVTGAAHSALLEPILDRFQEACAGLLAEPGQIPLISTLTAEVIDEA
TLNQADYWRRHMRQPVRFIQSIQAARKLGARVFVEMGPDAQLIASGQREYRDDAYWIASA
RRNQEASAVLNQALLQLYAAGVTLPWAALLAGDGQRISAPCYPFATERYWKEPATSACEP
ADAVFAAGLEVASSAATALELPRLEALKQCATRLHAIYVDRLVQRCTGDAIDNGVDAITI
MRHGRLMPRYQQLLQRLLNNCVVDGDYRCAEGRYYRARPIEHQQREILLTELADYCEGYQ
AIPDTIARAGDRLYDMMSGAEEPVAIIFPQGASDGVEVLYQEFSFGRYFNQIAAGVLRGI
VQARQPHQPLRILEVGGGTGGTTAWLLPELKDVPALEYHFTDISALFTRRAQQKFADYDF
VHYDELDLEQEAQSQGFAAQSFDLIVAANVIHATRHIGRTLDNLRPLLKPGGRLLMREIT
QPMRLFDFVFGPLVLPLQDIDAREGELFLTPHQWQQQCRRAGFSKVAWLPQDGSPTAAMS
EHIILATLPGQGASASSEPALEQPLPDNPDYLADWSDCAGQPERFTARWQEAWRRLSARH
GDDSPMKPPLVTAPQWLREVRLSWRNAAFSRGEMRVEARHPDGKWLPLAPDAPVPAPQTH
YHWRWRSLSIDCNSRPLAFRFSAGTLAREEALAQYGILHDPQAPSVLMIVDESEETLALA
TQMKEALTASPSGLIVVTRRAWRIKENEALSAAHHALWAMLRVAANEQPERLIAAIDLAE
NTPWETLRQGLSVVSLSQRWLAARNNGFWLPSLAPNAGYAAELPAKVFAGDNRWHLVTGA
FGGLGRLAVNWLREKGARRIALLAPRVDASWPGDTADVEIRVCRCDVGDAGELARVLDEL
ATSGGIAGAIHTAGVLADGPLQELDDHQLAAVFAVKAQAASKLLQTLGNHDARYLILYSS
AAAALGAPGQSAHALACGYLDGLAQQFSSLDTPKVLSIAWGAWGESGRAATTEMLTTLAD
RGMGALSDAEGRWHLEQAVMRGAAWRLAMRVFTDKMPPLQQALFNAAVTEHAATTAAPPA
DKHAFHGSISDKAAVMTWLKNRIAVQLRLNDPASLNADQDLLQLGMDSLLFLELSSDIQH
DLGVRINAERAWQDLSPHGLTQLICSQAETAPAVSPPEALQHDAAERYAPFPLTPIQHAY
WLGRTHLIGYGGVACHVLFEWDKRHDEFDLAVLEKAWNQLIARHDMLRMVVDADGQQRVL
ATTPTYRIPRDDLRALSPQEQRQALEKRRHELSYRVLPADQWPLFELVVSEIDDCRYRLH
MNLDLLQFDVQSFKVMMDDLAQVWRGETLPPLDITFRDYVMAEQARRQTTAWHDAWDYWQ
EKLPQLPSAPELPVVETPPETPHFTTFTSTLDKQEWQAVKQRWQQQGLTPSAALLTLFAA
TLERWSRTTAFTLNLTFFNRQPIHPQINQLIGDFTSVTLVDFNFSTPLTLQEQMQRTQQR
LWQNMAHSEVNGVEAIRELGRQRGSQRQPLMPVVFTSMLGMTLEGMAIDRAMSHLFGEPC
YVFTQTPQVWLDHQVMESDGALTFSWYCMDNVLEPGAAEAMFNDYCAILQAAIANPEGLK
TIDSGIAEHIPRRRWPLNAQTDYDLRDIEQAAQEYPGIQQARAELSENGALTLDIVVTED
PPPSAPLHDEHDLASLALPLPEQTQLDELEATWRWLEARALQGIAATLHRHRLFTTPEVA
HPFGEIVQALGAQASHRRLLRQWLQCLAEREWLVREGDSWRCRITLSDIPEPHEACPQTH
WSQALAQYLDACIARHDDLFSGQCSPLELLFNESLRVTEALYRENPASACLNRYTAQIAA
LCGAERILEVGAGTAATAEPVLKATRNTRLSYHFTDVSAQFLNDAQTRFHDESRVSYALF
DINQPLDFTAHPEAGYDLIIAVNVLHDASHVVQSLRRLKRLLKAGGRLLIVEATERNSVF
QLASVGFIEGLSGYRDFRRRDEKPMLTRSAWQEVLVQAGFANELAWPEQESSPLRQHLLV
ARSPGVNRPAKAAVSRYLQQRFGATLPALQIRQREALFTPLSAPPDAQIAPAESTPIAGG
EPALEKQVAELWQTLLSRPVARHHDFFALGGDSLMATRMVAQLNRRGIASASLQDLFTHS
TLSDFCAHLQACSSGEENPVPICQGGGDETLFVFHASDGDISAWLPLASALNMPVFGLQA
KSPQRFATLDRMIDEYVASIRRQQPHGPYALAGWSYGAFLAAGAAQRLDAKGEQVRLALI
DPVCRQDFRCANRTALLRLLAEGDTPLALPEHFDRLTPDRQLADFIDLARTAGMMAQNLT
LQAAEAWIDNIAHLLRLLTEHTLDETVPLPCLIVHAAMRPARWTPAETEWQTWIDRADSH
AIKASHWQIMLEPPHVQTCAQHIKRWLGATSTQPENTL