Protein Info for BWI76_RS14475 in Klebsiella michiganensis M5al

Annotation: serine/threonine transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 427 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 47 to 65 (19 residues), see Phobius details amino acids 99 to 118 (20 residues), see Phobius details amino acids 138 to 155 (18 residues), see Phobius details amino acids 163 to 183 (21 residues), see Phobius details amino acids 205 to 228 (24 residues), see Phobius details amino acids 249 to 271 (23 residues), see Phobius details amino acids 298 to 320 (23 residues), see Phobius details amino acids 346 to 369 (24 residues), see Phobius details amino acids 374 to 392 (19 residues), see Phobius details amino acids 405 to 426 (22 residues), see Phobius details TIGR00814: serine transporter" amino acids 16 to 416 (401 residues), 602.8 bits, see alignment E=1.6e-185

Best Hits

Swiss-Prot: 89% identical to SDAC_ECO57: Serine transporter (sdaC) from Escherichia coli O157:H7

KEGG orthology group: K03837, serine transporter (inferred from 90% identity to efe:EFER_0264)

MetaCyc: 89% identical to L-serine:H+ symporter SdaC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-71

Predicted SEED Role

"Serine transporter" in subsystem Glycine and Serine Utilization or Pyruvate Alanine Serine Interconversions or Threonine anaerobic catabolism gene cluster

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B3R9 at UniProt or InterPro

Protein Sequence (427 amino acids)

>BWI76_RS14475 serine/threonine transporter (Klebsiella michiganensis M5al)
METVQNTLVARESSGWRKSDTVWMLGLYGTAIGAGVLFLPINAGVGGLIPLIIMAILAFP
MTFFAHRGLTRFVLSGKNPGEDITEVVEEHFGTGAGKLITLLYFFAIYPILLVYSVAITN
TVDSFITHQLGLVSPPRAILSLILIVGMMGIVRFGEKMIVKAMSVLVFPFVFALMILALY
LIPQWNGAVLDTLSLSGASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYGED
AERKCSRILGFAHIMMVLTVMFFVFSCVLSLSPENLAEAKAQNISILSYLANHFNAPVIA
WMAPIIAMIAITKSFLGHYLGAREGFNGMVIKSLRGKGKSIEINKLNKITALFMLVTTWI
VATLNPSILGMIETLGGPVIAMILFLMPMYAINKVPAMRKYSGHISNAFVVVMGLIAISA
IFFSLFS