Protein Info for BWI76_RS14080 in Klebsiella michiganensis M5al

Annotation: hydrophobe/amphiphile efflux-1 family RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1035 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 341 to 360 (20 residues), see Phobius details amino acids 367 to 389 (23 residues), see Phobius details amino acids 395 to 414 (20 residues), see Phobius details amino acids 441 to 467 (27 residues), see Phobius details amino acids 474 to 498 (25 residues), see Phobius details amino acids 534 to 552 (19 residues), see Phobius details amino acids 869 to 887 (19 residues), see Phobius details amino acids 894 to 914 (21 residues), see Phobius details amino acids 920 to 945 (26 residues), see Phobius details amino acids 966 to 987 (22 residues), see Phobius details amino acids 997 to 1023 (27 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 2 to 1030 (1029 residues), 1422.3 bits, see alignment E=0 PF00873: ACR_tran" amino acids 3 to 1023 (1021 residues), 1151.5 bits, see alignment E=0 PF02355: SecD_SecF_C" amino acids 867 to 1023 (157 residues), 26.4 bits, see alignment E=4.4e-10

Best Hits

Swiss-Prot: 52% identical to ACRD_ECOLI: Probable aminoglycoside efflux pump (acrD) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 92% identity to eae:EAE_19065)

MetaCyc: 52% identical to multidrug efflux pump RND permease AcrD (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-1551; TRANS-RXN-1552; TRANS-RXN-360

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B3Q1 at UniProt or InterPro

Protein Sequence (1035 amino acids)

>BWI76_RS14080 hydrophobe/amphiphile efflux-1 family RND transporter (Klebsiella michiganensis M5al)
MLARFFVFRPVFAAVIAICIMAAGALALLTLPVEQYPDIAPPAVNVTANYTGASAETVED
SVTQVLEQQIKGIDGLIYFSSSSSSAGQARISLSFDQGVNPDMAQVQVQNAVNQAITRLP
QEVQQQGITVTKSQGDSLMVVALYDKSEQLTSLDISDFLVSSLQEPLSRVEGVGETTVFG
AQYAMRIWLNPLQLTSYGLMPSDVQAAIEAQNSQVTSGEIGSLPTLEGQYLNATVATQSR
LERPEQFENIILRTNSDGSVVYLRDVARVEIGAENYQNQTTLNGYSSAGISIQLASGANA
LETAKKVRAEVERLSSRFPQGVVAAYPRDSTPFVTVSIESVVHTLIEAILFVVAVMYLFL
QSWRATLIPTLTVPVVLLGTFGILSLLGYSINTLTLFAMVLAIGLLVDDAIVVVENVERL
MAEEDLTPLEATLRSMNEITGALIGIALVLSAVFIPMALFGGSVGIIYRQFTVTIVSAMA
LSALVALTLTPTLCAHLLKPGHMKKGRFFTLFNRGVTISQNRYLATLQRITARPFRFVCL
ALILTFLMLWQYQKLASGFLPEEDQGAVMVQYTLPSGSPMSMTEEVGADIARYFMTEEED
NLNVIFMVTGRNNAGSGQNVGMAFAELKHWDLRPGEKNSAQAIISRANQYFNKNARQANI
SVMSPPTVRGLGQSSGFELWLQDSAENGSAALMQAQTTLLNAARENPALDAVRINSLEEK
AQLQVNVDRQKAQAQGLDQADINNTLSAAWGGVYVNDFIDRGRVKRVYMQGDAAWRSTPE
NLSAWFVRGDSNNMASFDSFSSLRWTTGPQMLQRFNGLSAVQFQGGAAPGVSSGAAMAEM
ADLVSSMNGFDLQWSGLSWQEQSSSVQTLWVYLASLAFMFLCLAALYESWSVPIAVMLII
PLGIIGAISASLLAGYENDIYFQVGMLTTMGLSSKNAILIVEFALAQFQQGKSLSEATLE
GARLRLRPIVMTSLAFVVGVIPLVLSTGAGASSQREIGTAVIGGMLTGTLLTLFFAPLFF
LLVQQGMMRLKRRKP