Protein Info for BWI76_RS13985 in Klebsiella michiganensis M5al

Annotation: urea carboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1201 PF00289: Biotin_carb_N" amino acids 1 to 109 (109 residues), 141.8 bits, see alignment E=5.4e-45 TIGR02712: urea carboxylase" amino acids 2 to 1196 (1195 residues), 1813.5 bits, see alignment E=0 PF02786: CPSase_L_D2" amino acids 116 to 318 (203 residues), 204 bits, see alignment E=9.3e-64 PF07478: Dala_Dala_lig_C" amino acids 139 to 291 (153 residues), 35.8 bits, see alignment E=2.7e-12 PF02785: Biotin_carb_C" amino acids 338 to 447 (110 residues), 96.7 bits, see alignment E=3.9e-31 TIGR00724: biotin-dependent carboxylase uncharacterized domain" amino acids 454 to 773 (320 residues), 283 bits, see alignment E=2.6e-88 PF02626: CT_A_B" amino acids 478 to 750 (273 residues), 308 bits, see alignment E=2.9e-95 PF02682: CT_C_D" amino acids 801 to 1018 (218 residues), 135.3 bits, see alignment E=1.1e-42 PF00364: Biotin_lipoyl" amino acids 1137 to 1196 (60 residues), 49.2 bits, see alignment 1.7e-16

Best Hits

Predicted SEED Role

"Urea carboxylase (EC 6.3.4.6)" in subsystem Urea decomposition (EC 6.3.4.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B3N5 at UniProt or InterPro

Protein Sequence (1201 amino acids)

>BWI76_RS13985 urea carboxylase (Klebsiella michiganensis M5al)
MFDTLLIANRGAIACRILRTLRAMQVKGVAVYSEADLSSLHIRDADEALSLGDGPAAQTY
LATEKIIAAAQQSGARAIHPGYGFLSENAAFAEACEAAGLAFVGPTPRQLRVFGLKHTAR
ALAKAEGVPLLEGSELLADSDEACRAAEAVGYPVMLKSTAGGGGIGMRVCRDARELTEAF
ATVQRLGQNNFSDAGVFLEKYIERARHLEVQIFGDGRGDVIALGVRDCSVQRRNQKVIEE
TPAPNLPEGTAQALCAAAIALGKAVSYRSAGTVEFVYDSTARQFYFLEVNTRLQVEHGVT
EQVWGVDLVRWMIELAAGDLPPLDVLAAGLRPQGHAIQARLYAEDPGRQFQPSPGLLTEA
IFPPADGAALRIDRWVEAGCEVPPFFDPMLAKTIAWRPSRDEAIAGLAQALAETRLYGVE
TNRLYLLQILGFAPFTEGEPWTRCLEQLRYRAATVEVLSAGTQTSVQDYPGRLGYWAVGV
PPSGPMDDRALRLGNRLLGNAEGEAALEITLNGPTLKFNTDVQAVVCGAPLAVTLDGVDQ
PLDRVFTIPAGATLKLGAINGAGVRSYLCLSGGIQVPDYLGSKSTFTLGQFGGHGGRALR
GGDVLHLAPRAAARVGDQLPAALRTALAQVRTLRVIYGPHGAPEFFTPAYIATFFATDWE
VHFNSSRTGVRLIGPKPLWARDSGGEAGLHPSNIHDNPYAVGAVDFTGDMPVILGPDGPS
LGGFVCPVTVIEADLWQLGQLKAGDKVRFVAVDLPTARRLAQGRRAELTTLSHQAIAWQP
APLTSPVVMTCGEADKRLVARLSGDTHLLLEAGEPELDLVLRFRIHALMQALEAQSAEGV
IDITPGIRSLQIHFQPETLPLETLLARVRGEWSTVCLSDDLQVPTRVVYLPLSWDDPACR
KAIDKYMTTVRQDAPWCPSNLEFIRRINDLPDEQAVWNTVFDASYLVMGLGDVYLGAPVA
TPLDPRHRLVTTKYNPARTWTAENSVGIGGAYLCVYGMEGPGGYQFVGRTLQMWNRYHDV
ADFAGKPWLLRFFDQLRFYPVSAEELLQIRRDFPLGRYPLRIENSTLRLAEYQQFLHREA
HSIGAFREHQQRAFNAERDRWIASGQAHFDSQEGAVDEGGDAPLRQGEQGVESPISGNLW
QVQTAAGSRVRAGDVLVVLESMKMEIPLLAPCDGVIQQVHVQPGSAVRAGQRVAVIIEEK
A