Protein Info for BWI76_RS13685 in Klebsiella michiganensis M5al

Annotation: IclR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 265 PF09339: HTH_IclR" amino acids 23 to 71 (49 residues), 52.1 bits, see alignment 4.4e-18 PF01614: IclR" amino acids 140 to 263 (124 residues), 96.9 bits, see alignment E=8.7e-32

Best Hits

Swiss-Prot: 50% identical to PCAR_PSEPU: Pca regulon regulatory protein (pcaR) from Pseudomonas putida

KEGG orthology group: None (inferred from 91% identity to kpu:KP1_2942)

Predicted SEED Role

"Pca regulon regulatory protein PcaR" in subsystem Protocatechuate branch of beta-ketoadipate pathway

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B3I1 at UniProt or InterPro

Protein Sequence (265 amino acids)

>BWI76_RS13685 IclR family transcriptional regulator (Klebsiella michiganensis M5al)
MSEKQPGTLSARQAEHGPNFMLSLARGLEVLNAFSPQRQRLTISQLSQKTQISRAAVRRC
LYTLAALGMVHSPDGRSYELLPRVLAVGHAYLAGTPLAKVAQSALDTLGKNLGESCSAAT
LDGDNVLYIARTAVNNLLSVDIGRGSRLPAWATSMGRVLLSALPEEQLEVTLSRANLIRY
TPHTLCDIPGLREEIARVRMQGYALADRQIEVGLCSLAVPLLSRSGQVVAALNVGVPAGS
TNAAALKEKALAPLRRAAMALSLQL