Protein Info for BWI76_RS13210 in Klebsiella michiganensis M5al

Annotation: aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 22 to 475 (454 residues), 554.2 bits, E=1e-170

Best Hits

Swiss-Prot: 88% identical to ALDA_ECOLI: Lactaldehyde dehydrogenase (aldA) from Escherichia coli (strain K12)

KEGG orthology group: K07248, lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase [EC: 1.2.1.21 1.2.1.22] (inferred from 93% identity to kpu:KP1_2509)

MetaCyc: 88% identical to aldehyde dehydrogenase A (Escherichia coli K-12 substr. MG1655)
Lactaldehyde dehydrogenase. [EC: 1.2.1.22]; Glycolaldehyde dehydrogenase. [EC: 1.2.1.22, 1.2.1.21]

Predicted SEED Role

"Aldehyde dehydrogenase A (EC 1.2.1.22) / Glycolaldehyde dehydrogenase (EC 1.2.1.21)" in subsystem L-rhamnose utilization or Methylglyoxal Metabolism (EC 1.2.1.21, EC 1.2.1.22)

MetaCyc Pathways

• superpathway of fucose and rhamnose degradation (11/12 steps found)
• superpathway of glycol metabolism and degradation (7/7 steps found)
• D-arabinose degradation II (4/4 steps found)
• ethylene glycol degradation (2/2 steps found)
• methylglyoxal degradation V (2/3 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• lactate biosynthesis (archaea) (3/5 steps found)
• superpathway of methylglyoxal degradation (5/8 steps found)
• methylglyoxal degradation IV (1/3 steps found)
• L-rhamnose degradation II (4/8 steps found)
• superpathway of pentose and pentitol degradation (21/42 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.22

Use Curated BLAST to search for 1.2.1.21 or 1.2.1.22

Sequence Analysis Tools

See A0A285B394 at UniProt or InterPro

Protein Sequence (479 amino acids)

>BWI76_RS13210 aldehyde dehydrogenase (Klebsiella michiganensis M5al)
MTAPVQHPMYIDGQFEPGRGDAWIDVINPATEALLSRIPDGSAEDARRAILAAERAQPGW
EALPAIERARWLRKIAAGIRERAEEIAALIVAEGGKIQQLAAVEVSFTADYLDYMAEWAR
RYEGEIVQSDRTGENILVFKRALGVTTGILPWNFPFFLIARKLAPALITGNTIVIKPSEF
TPNNAIAFAQIVHDIGLPKGVFNLVLGRGETVGQELASNPKVAMVSMTGSVAAGEKIMAA
AAKNITKVCLELGGKAPAIVMDDADLELAVKAVVDSRVINSGQVCNCVERVYVQKGIYDR
FVNRLGEALKAVQFGDPASRDDIAMGPLINAAALARVEQKVAKAVAQGARVALGGKAVTG
RGYFYPPTLLLDVRQEMDIVHEETFGPVLPVVAFDTLEEALAMANDSDYGLTSSIYTRDL
NVAMKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGRHGLNEYLQTQVVYLQA