Protein Info for BWI76_RS13085 in Klebsiella michiganensis M5al
Annotation: bifunctional oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 87% identical to PAAZ_ECOLI: Bifunctional protein PaaZ (paaZ) from Escherichia coli (strain K12)
KEGG orthology group: None (inferred from 92% identity to eae:EAE_20525)MetaCyc: 87% identical to fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase (Escherichia coli K-12 substr. MG1655)
3-hydroxybutyryl-CoA dehydratase. [EC: 4.2.1.55]; RXNMETA-12671 [EC: 4.2.1.55, 3.3.2.12]; RXNMETA-12672 [EC: 4.2.1.55, 3.3.2.12, 1.2.1.91]
Predicted SEED Role
"Aldehyde dehydrogenase (EC 1.2.1.3), PaaZ" in subsystem Aromatic Amin Catabolism (EC 1.2.1.3)
MetaCyc Pathways
- superpathway of phenylethylamine degradation (11/11 steps found)
- phenylacetate degradation I (aerobic) (9/9 steps found)
- ethanol degradation II (3/3 steps found)
- ethanol degradation IV (3/3 steps found)
- phytol degradation (3/4 steps found)
- acetyl-CoA fermentation to butanoate (5/7 steps found)
- ethanol degradation III (2/3 steps found)
- hypotaurine degradation (2/3 steps found)
- mitochondrial NADPH production (yeast) (3/5 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (5/8 steps found)
- (2S)-ethylmalonyl-CoA biosynthesis (2/4 steps found)
- fatty acid α-oxidation I (plants) (2/4 steps found)
- putrescine degradation III (2/4 steps found)
- histamine degradation (1/3 steps found)
- 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
- octane oxidation (2/5 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
- serotonin degradation (3/7 steps found)
- dopamine degradation (1/5 steps found)
- aromatic biogenic amine degradation (bacteria) (3/8 steps found)
- ceramide degradation by α-oxidation (2/7 steps found)
- sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
- alkane oxidation (1/6 steps found)
- limonene degradation IV (anaerobic) (1/7 steps found)
- noradrenaline and adrenaline degradation (4/13 steps found)
- ethylmalonyl-CoA pathway (2/11 steps found)
- ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
KEGG Metabolic Maps
- 1,2-Dichloroethane degradation
- 3-Chloroacrylic acid degradation
- Arginine and proline metabolism
- Ascorbate and aldarate metabolism
- Butanoate metabolism
- Fatty acid metabolism
- Glycerolipid metabolism
- Glycolysis / Gluconeogenesis
- Histidine metabolism
- Limonene and pinene degradation
- Lysine degradation
- Propanoate metabolism
- Pyruvate metabolism
- Tryptophan metabolism
- Urea cycle and metabolism of amino groups
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.3
Use Curated BLAST to search for 1.2.1.3 or 1.2.1.91 or 3.3.2.12 or 4.2.1.55
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285B3H9 at UniProt or InterPro
Protein Sequence (681 amino acids)
>BWI76_RS13085 bifunctional oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (Klebsiella michiganensis M5al) MQQLASYLSGTWQTGRGHARTIHHAISGDALWEVTSAGLDMAQARRFAIERGGKALQAMT FIERSAMLKAVARHLLEQKAALYAISAETGATRSDSWVDIEGGIGTLFTYAGLGSRELPD DTLWPEDELIPLSKQGGFAARHVLTSKSGVAVHINAFNFPCWGMLEKLAPTWLAGMPAII KPATATAQLTQAMVKMIVDSGLVPEGAISLICGGAGDLLDHLDSQDVVTFTGSARTGQQL RVHPNLVAKSIPFTMEADSLNCCVLGDDVTPEQPEFALFIREVVREMTAKAGQKCTAIRR IIVPQAQVKAVSDALIARLQNVVVGDPAQEGVKMGALVNYEQRQDVQDNVNRLVAAGCDV LLGGQADLRAAGAFFPPTLLFCPQPDETPAVHAIEAFGPVATLMPYQNIEHAMSLARAGE GSLAGTLVTASGELARAFILGAARTHGRIQILNESSSAESTGHGSPLPQLVHGGPGRAGG GEELGGLRAVKHYMQRTAIQGSPTMLAAIGQQWVRGAEVVEDRIHPFRKYFEEIQPGDSL LTPRRTLTEADIVNFACLSGDHFYAHMDKIAAAESIFGERVVHGYFLISAAAGLFVDAGV GPVIANYGMENLRFIEPVKPGDTIQVRLTCKRKTVKRQRSAEEKATGVVEWAVEIFNQHQ QAVALYSILTLVARQQGDFAG