Protein Info for BWI76_RS12880 in Klebsiella michiganensis M5al

Annotation: aspartate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01745: aspartate-semialdehyde dehydrogenase
  • amino acids 2 to 368 (367 residues), 516.3 bits, E=2e-159
• PF01118: Semialdhyde_dh
  • amino acids 3 to 121 (119 residues), 85.9 bits, E=2.9e-28
• PF02774: Semialdhyde_dhC
  • amino acids 144 to 355 (212 residues), 126.9 bits, E=1e-40

Best Hits

Swiss-Prot: 54% identical to DHAS_NEIMA: Aspartate-semialdehyde dehydrogenase (asd) from Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

KEGG orthology group: None (inferred from 90% identity to kpe:KPK_2597)

MetaCyc: 54% identical to aspartate-semialdehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Aspartate-semialdehyde dehydrogenase. [EC: 1.2.1.11]

Predicted SEED Role

"Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)" in subsystem Lysine Biosynthesis DAP Pathway or Threonine and Homoserine Biosynthesis (EC 1.2.1.11)

MetaCyc Pathways

• aspartate superpathway (24/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (9/9 steps found)
• superpathway of L-methionine biosynthesis (transsulfuration) (9/9 steps found)
• superpathway of L-homoserine and L-methionine biosynthesis (8/8 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• superpathway of L-threonine biosynthesis (6/6 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (10/12 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• L-homoserine biosynthesis (3/3 steps found)
• dipicolinate biosynthesis (3/4 steps found)
• norspermidine biosynthesis (4/6 steps found)
• L-lysine biosynthesis II (6/9 steps found)
• ectoine biosynthesis (3/5 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)
• L-methionine biosynthesis IV (2/4 steps found)
• spermidine biosynthesis II (2/4 steps found)
• superpathway of polyamine biosynthesis III (4/8 steps found)
• 3-dehydroquinate biosynthesis II (archaea) (3/7 steps found)
• cremeomycin biosynthesis (2/7 steps found)
• grixazone biosynthesis (2/8 steps found)
• platensimycin biosynthesis (6/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of plant hormones
• Glycine, serine and threonine metabolism
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.11

Use Curated BLAST to search for 1.2.1.11

Protein Sequence (372 amino acids)

>BWI76_RS12880 aspartate-semialdehyde dehydrogenase (Klebsiella michiganensis M5al)
MKQVGIVGWRGMVGSVLLQRMIEENDFDNISAHFFSTSSAGAAGPVIDGISYTLKDANSV
SALAEMDIIITCQGGDYTKAIYPNLLNHGWGGYWIDAASALRMDEKACIILDPVNRNNID
RAIKEGIKLFVGGNCSITLSLMGLAGLIKADLIEWMSVMTYQSASGAGAQYVRELIAQSA
YISRHLSPDELASSGSVLPLVNKVSELINSADMPTQNFGAPLMGSIIPWIDSDLGDGNSR
EEWKGEAETNKILGLSPGTIPVNGLCIRVGVIRCHSAAITLKLKREVNEEEFAELVMNSH
PWVNYVPNNKEESVSTLTPAHISGSLKVGIGRYKKMSLNNEPIYSVLTVGDQLLWGAAEP
LRRMLNILSGKA