Protein Info for BWI76_RS12820 in Klebsiella michiganensis M5al
Annotation: NAD-dependent phenylacetaldehyde dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 85% identical to FEAB_ECOLI: Phenylacetaldehyde dehydrogenase (feaB) from Escherichia coli (strain K12)
KEGG orthology group: None (inferred from 93% identity to eae:EAE_20545)MetaCyc: 85% identical to phenylacetaldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Phenylacetaldehyde dehydrogenase. [EC: 1.2.1.39]
Predicted SEED Role
"Phenylacetaldehyde dehydrogenase (EC 1.2.1.39)" in subsystem Aromatic Amin Catabolism (EC 1.2.1.39)
MetaCyc Pathways
- superpathway of phenylethylamine degradation (11/11 steps found)
- phenylethylamine degradation I (2/2 steps found)
- L-phenylalanine degradation II (anaerobic) (2/3 steps found)
- phenylethanol degradation (1/2 steps found)
- phenylethylamine degradation II (1/2 steps found)
- styrene degradation (1/3 steps found)
- L-phenylalanine degradation IV (mammalian, via side chain) (5/9 steps found)
- anaerobic aromatic compound degradation (Thauera aromatica) (3/27 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.39
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285B379 at UniProt or InterPro
Protein Sequence (499 amino acids)
>BWI76_RS12820 NAD-dependent phenylacetaldehyde dehydrogenase (Klebsiella michiganensis M5al) MSTSQVALLASVQQFLDRQHGLYLDGTQQAAESEQRLTVWNPATGQAIASTADANAADVD RAVMSAWRAFVSRSWAGRTPADRERILLRFADLVEQHGEELAQLETLEQGKSINISRAFE VGCTLNWMRYTAGLTTKISGRTLDVSIPFPAGGRYQAWTKKEPVGVVAGIVPWNFPLMIG MWKVMPALAAGCSIVIKPSETTPLTLLRVAELATEAGVPDGVFNVVTGSGAGCGAALTSH PLVAKVSFTGSTATGKQIARVAADRLTRVTLELGGKNPAIVLKDADPQWVIEGLMTGSFL NQGQVCAASSRIYIEAPLFDTLVSGFEQAVKSLQVGPGMLESSQINPVVSQAHCAKVAAY LDEARQQKAELISGHAGPDAQGYYIAPTLVINPDAGLRLCREEVFGPVVNLVRVADGEEA LLLANDSDFGLTASVWTRDLTQALSYTDRLQAGTVWVNSHTLIDANLPFGGMKQSGTGRD FGPDWLDDWCETKSVCVRY