Protein Info for BWI76_RS12590 in Klebsiella michiganensis M5al

Annotation: helix-turn-helix-type transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 242 PF13411: MerR_1" amino acids 3 to 70 (68 residues), 59.8 bits, see alignment E=2.3e-20 PF00376: MerR" amino acids 4 to 41 (38 residues), 51.1 bits, see alignment 9.2e-18

Best Hits

Swiss-Prot: 44% identical to MLRA_ECOLI: HTH-type transcriptional regulator MlrA (mlrA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 90% identity to kva:Kvar_4543)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B2Y5 at UniProt or InterPro

Protein Sequence (242 amino acids)

>BWI76_RS12590 helix-turn-helix-type transcriptional regulator (Klebsiella michiganensis M5al)
MTYSIGEFAQLCGINATTLRAWQRRYGLLKPQRTDGGHRLYNDDDIQQALKILDWVKKGV
PVSQVKPLLARPGARRTNNWLTLQENMLQRLKEGKIESLRQLIYDAGRESPRPELVTEVL
RPLRSQVSANVPAIMTLREILDGIIIAYTSFCLEGDKKAPGDNYLITGWHLTDACEIWLE
ALKRTGQGHRIDVLPAPPATLAPEILPERKWLLVTTGKLSPARQKQVERWQQQVVSLEIV
AL