Protein Info for BWI76_RS11950 in Klebsiella michiganensis M5al

Annotation: phosphatidylglycerophosphatase B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01569: PAP2
  • amino acids 80 to 231 (152 residues), 92.3 bits, E=1.1e-30

Best Hits

Swiss-Prot: 73% identical to PGPB_ECOLI: Phosphatidylglycerophosphatase B (pgpB) from Escherichia coli (strain K12)

KEGG orthology group: K01096, phosphatidylglycerophosphatase B [EC: 3.1.3.27] (inferred from 82% identity to kpu:KP1_2317)

MetaCyc: 73% identical to phosphatidylglycerophosphatase B (Escherichia coli K-12 substr. MG1655)
RXN-11277 [EC: 3.6.1.75]; Undecaprenyl-diphosphatase. [EC: 3.6.1.75, 3.6.1.27]; Phosphatidylglycerophosphatase. [EC: 3.6.1.75, 3.6.1.27, 3.1.3.27]

Predicted SEED Role

"Phosphatidylglycerophosphatase B (EC 3.1.3.27)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 3.1.3.27)

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (11/12 steps found)
• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• polyisoprenoid biosynthesis (E. coli) (5/5 steps found)
• cardiolipin biosynthesis I (3/3 steps found)
• cardiolipin biosynthesis II (3/3 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (10/13 steps found)
• di-trans,poly-cis-undecaprenyl phosphate biosynthesis (2/2 steps found)
• cardiolipin biosynthesis III (2/3 steps found)
• phosphatidate metabolism, as a signaling molecule (2/5 steps found)
• type I lipoteichoic acid biosynthesis (S. aureus) (5/17 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism
• Peptidoglycan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.27, 3.6.1.27

Use Curated BLAST to search for 3.1.3.27 or 3.6.1.27 or 3.6.1.75

Sequence Analysis Tools

See A0A285B2P9 at UniProt or InterPro

Protein Sequence (255 amino acids)

>BWI76_RS11950 phosphatidylglycerophosphatase B (Klebsiella michiganensis M5al)
MLLIARRTAVGAALLLIMPAVIWITGWKWHPGLSAGAMKLLYWITETVTQPWGIITHVIL
CAWFLWCLRFRLRAAIVLFLILAAAILVGQGMKSWLKDRVQEPRPFVIWLEQTRQVPVTQ
FYALKRKDRAKLVHEQLAQEQQIPKFLRKHWQKETGFAFPSGHTMFAASWALLGVGLLWP
RRRWVTIALLLTWATAVMGSRLALGMHWPQDLIVATLISWLLVTLATWLAQRFCGPLSPP
GEEAQDIKKRAAAPE