Protein Info for BWI76_RS11755 in Klebsiella michiganensis M5al

Annotation: catalase HPII

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 752 PF00199: Catalase" amino acids 80 to 465 (386 residues), 599.4 bits, see alignment E=4.8e-184 PF06628: Catalase-rel" amino acids 498 to 561 (64 residues), 67.3 bits, see alignment E=1.6e-22 PF18011: Catalase_C" amino acids 598 to 744 (147 residues), 44.5 bits, see alignment E=1.8e-15

Best Hits

Swiss-Prot: 84% identical to CATE_ECOLI: Catalase HPII (katE) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 86% identity to eae:EAE_21525)

MetaCyc: 84% identical to catalase HPII (Escherichia coli K-12 substr. MG1655)
Catalase. [EC: 1.11.1.21, 1.11.1.6]; RXN-8073 [EC: 1.11.1.21, 1.11.1.6]

Predicted SEED Role

"Catalase (EC 1.11.1.6)" in subsystem Oxidative stress or Photorespiration (oxidative C2 cycle) (EC 1.11.1.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.6

Use Curated BLAST to search for 1.11.1.21 or 1.11.1.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B2H5 at UniProt or InterPro

Protein Sequence (752 amino acids)

>BWI76_RS11755 catalase HPII (Klebsiella michiganensis M5al)
MSDKHPNPQPHQSPVHDDREAKPGLDALAPEDQNWRPTPHPTAPGEEPTAPGSMKAPDTH
SEKLDALEKHRKGGEDFALTTNQGVRIADDQNSLRAGKRGPTLLEDFILREKITHFDHER
IPERIVHARGSAAHGYFQAYSDLSDITKADFLSSPEKKTPVFVRFSTVQGGAGSADTVRD
IRGFATKFYTDEGIFDLVGNNTPIFFIQDALKFPDFVHAVKPEPHWAVPQGQSAHDTFWD
YVSLQPETLHNVMWAMSDRGLPRSYRTMEGFGIHTFRLINAQGKATFVRFHWKPVAGKAS
LVWDESQKLTGRDPDFHRRDLWEAIEAGDYPEYELGLQLIPEEDEFAFDFDLLDPTKLIP
EALVPVQRVGKMVLNRNPDNFFAENEQAAFHPGHIVPGIDFSNDPLLQGRLFSYTDTQIS
RLGGPNFHEIPINKPTCPYHNFQRDGMHRMDIDTNPANYEPNSINDNWPRETPPAAKRGG
FESYAERVDGEKIRQRSPSFGEYYSHPLLFWRSQTPIEQQHIIDGFSFELSKVVREWIRE
RVVDQLAHIDLQLAQAVGKNLGIELTDEQRSITPPPDVNGLKKDPTLSLYAIPSGDVKGR
VVAVLLNDRPVAKELLALLKTLKAHGVHAKLLYSRMGKVKADDGSELPVAGTFAGSPSLT
VDAVIVPGGDLQSLSNNGDFHYYLLEAYKHLKPILLAGDARQCKAPLQIASQGEEGVVET
DAIDSQALDELITLMAAHRVWSRNAKIAAIPA