Protein Info for BWI76_RS11100 in Klebsiella michiganensis M5al

Annotation: beta-ketoacyl-[acyl-carrier-protein] synthase II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 413 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF00109: ketoacyl-synt" amino acids 4 to 247 (244 residues), 217.3 bits, see alignment E=2.8e-68 TIGR03150: beta-ketoacyl-acyl-carrier-protein synthase II" amino acids 4 to 411 (408 residues), 646.6 bits, see alignment E=6.4e-199 PF02801: Ketoacyl-synt_C" amino acids 255 to 369 (115 residues), 139.7 bits, see alignment E=4.6e-45

Best Hits

Swiss-Prot: 94% identical to FABF_SHIFL: 3-oxoacyl-[acyl-carrier-protein] synthase 2 (fabF) from Shigella flexneri

KEGG orthology group: K09458, 3-oxoacyl-[acyl-carrier-protein] synthase II [EC: 2.3.1.179] (inferred from 97% identity to kpn:KPN_01093)

MetaCyc: 94% identical to 3-oxoacyl-[acyl carrier protein] synthase 2 (Escherichia coli K-12 substr. MG1655)
Beta-ketoacyl-acyl-carrier-protein synthase II. [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179,2.3.1.41 [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179,2.3.1.41 [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179 [EC: 2.3.1.179, 2.3.1.41]

Predicted SEED Role

"3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.179)" (EC 2.3.1.179)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.179, 2.3.1.41

Use Curated BLAST to search for 2.3.1.179 or 2.3.1.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B2H4 at UniProt or InterPro

Protein Sequence (413 amino acids)

>BWI76_RS11100 beta-ketoacyl-[acyl-carrier-protein] synthase II (Klebsiella michiganensis M5al)
MSKRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCD
DFISRKEQRKMDAFIQYGIVAGIQAMQDSGLEVTEENATRIGAAIGSGIGGLGLIEENHS
SLVKGGPRKISPFFVPSTIVNMVAGHLTIMFGLRGPSISIATACTSGVHNIGHAARVIAY
GDADAMVAGGAEKASTPLGVGGFGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMVV
LEEYEHAKKRGAKIYAEIVGFGMSSDAYHMTSPPEDGAGAALAMVNAIRDAGIDASQIGY
VNAHGTSTPAGDKAEAQAVKSVFGDAASRVMVSSTKSMTGHLLGAAGAVESIYSILALRD
SAVPPTINLDNPDEGCDLDFVPHEARQVSGLEYTLCNSFGFGGTNGSLIFKKV