Protein Info for BWI76_RS11000 in Klebsiella michiganensis M5al

Annotation: glutaredoxin 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 215 TIGR02182: glutaredoxin, GrxB family" amino acids 2 to 210 (209 residues), 326.5 bits, see alignment E=3.8e-102 PF13417: GST_N_3" amino acids 3 to 75 (73 residues), 44.7 bits, see alignment E=2e-15 PF13409: GST_N_2" amino acids 8 to 71 (64 residues), 32 bits, see alignment E=2.2e-11 PF04399: Glutaredoxin2_C" amino acids 86 to 214 (129 residues), 164.2 bits, see alignment E=2e-52

Best Hits

Swiss-Prot: 87% identical to GLRX2_ECOLI: Glutaredoxin 2 (grxB) from Escherichia coli (strain K12)

KEGG orthology group: K03675, glutaredoxin 2 (inferred from 88% identity to ent:Ent638_1578)

MetaCyc: 87% identical to reduced glutaredoxin 2 (Escherichia coli K-12 substr. MG1655)
Protein-disulfide reductase (glutathione). [EC: 1.8.4.2]

Predicted SEED Role

"Glutaredoxin 2" in subsystem Glutaredoxins or Glutathione: Redox cycle

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B227 at UniProt or InterPro

Protein Sequence (215 amino acids)

>BWI76_RS11000 glutaredoxin 2 (Klebsiella michiganensis M5al)
MKLYIYDHCPFCLKARMIFGLKNIPVELIALLNDDEVTPTRMIGQKMAPILQKDDSRYMP
ESMDIVHYVDKLDGKPLLTGKRNPAIETWLRKVNGYANRLLIPRFAKSAFDEFATPEARA
YFVKKKEAAIGSFADHLAHSPGLVKNISDDLRALDKSIVQPNAVNGELSEDDIHLFPLLR
NLTLVAGVNWPSRVAAYRDNMAKQTQINLLSSMAI