Protein Info for BWI76_RS09935 in Klebsiella michiganensis M5al

Annotation: paraquat-inducible membrane protein A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 422 transmembrane" amino acids 53 to 73 (21 residues), see Phobius details amino acids 99 to 122 (24 residues), see Phobius details amino acids 134 to 158 (25 residues), see Phobius details amino acids 164 to 185 (22 residues), see Phobius details amino acids 255 to 277 (23 residues), see Phobius details amino acids 304 to 329 (26 residues), see Phobius details amino acids 350 to 371 (22 residues), see Phobius details amino acids 377 to 399 (23 residues), see Phobius details TIGR00155: integral membrane protein, PqiA family" amino acids 1 to 408 (408 residues), 586.1 bits, see alignment E=2e-180 PF04403: PqiA" amino acids 49 to 200 (152 residues), 130 bits, see alignment E=3.5e-42 amino acids 253 to 408 (156 residues), 182.9 bits, see alignment E=1.9e-58

Best Hits

Swiss-Prot: 82% identical to PQIA_ECOL6: Intermembrane transport protein PqiA (pqiA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03808, paraquat-inducible protein A (inferred from 93% identity to kpu:KP1_1951)

Predicted SEED Role

"Paraquat-inducible protein A" in subsystem Oxidative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B1H7 at UniProt or InterPro

Protein Sequence (422 amino acids)

>BWI76_RS09935 paraquat-inducible membrane protein A (Klebsiella michiganensis M5al)
MCDHHHAARHILCRQCDLLVALPQLEHRQKATCPRCGTTLTTSWDAPRQRPTAYALVALF
MLLLANLFPFIYMKVGGISSEIELLEIPNVLFTEDYASLGTFFLLFVQLVPAFCLVTILL
LVNRVGMPSGLKAFLARILFHLKTWGMAEIFLAGVLVSFVKLMAYGDIGIGLSFIPWCMF
CLLQLRTFQCVDRRWLWDDIAPMPPIKQPLKVGVSGLRQGLRSCSCCTAVLPMDEAVCPR
CRTRGTARRKNSLQWTLALLVTSLILYMPANILPIMITDLLGDKMPSTIMAGVILLWSEG
SYPVAMVIFIASIMVPTLKMIAIGWLCWNASGKGERDSERMHLIYEVVEFVGRWSMIDVF
VIAVLSALVRIGGLMNIYPAIGAVMFALVVVMTMFSAMTFDPRLLWDREPDSSREERLQH
GK