Protein Info for BWI76_RS09045 in Klebsiella michiganensis M5al

Annotation: alpha-glucosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 787 PF13802: Gal_mutarotas_2" amino acids 26 to 213 (188 residues), 141.7 bits, see alignment E=6.6e-45 PF01055: Glyco_hydro_31_2nd" amino acids 263 to 587 (325 residues), 297.5 bits, see alignment E=2.9e-92 PF21365: Glyco_hydro_31_3rd" amino acids 596 to 681 (86 residues), 83.7 bits, see alignment E=2.1e-27

Best Hits

KEGG orthology group: K01187, alpha-glucosidase [EC: 3.2.1.20] (inferred from 91% identity to kpu:KP1_1811)

Predicted SEED Role

"Alpha-glucosidase (EC 3.2.1.20)" in subsystem D-Galacturonate and D-Glucuronate Utilization or Maltose and Maltodextrin Utilization (EC 3.2.1.20)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.20

Use Curated BLAST to search for 3.2.1.20

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B1D8 at UniProt or InterPro

Protein Sequence (787 amino acids)

>BWI76_RS09045 alpha-glucosidase (Klebsiella michiganensis M5al)
MKTLKNWTLHQRLEHHVELLVDGQHTLCLYVLEENMFRVLLKRHGQLALDRTWSIAPGQD
VPWEGRPREELSGFSLPAWQLTEHSDALTIATDQLRVTVHQPLWLEWRYRDEAGEWQPLA
NDRPTSAYLANAHGDGVAHYLSRRKDERFYGLGEKAGDLQRNGKRYEMRNLDAMGYNAAS
TDPLYKHIPFTITQRSDVSYGLFYDNLSSCWLDLGNEIDNYHTAYRRWQAEAGDIDYYLF
SGKRVLDITKAFVRLTGKTLFGPKWSLGYSGSTMHYTDAPDAQNQLMNFIRLCDEHAIPC
DSFQLSSGYTSINGKRYVFNWNNDKVPQPKVMSQAFHDAGLKLAANIKPCLLQDHPRYHE
VAERGLFIRDSQADAPERSSFWDDEGSHLDFTNPQTVAWWQEGVTTQLLELGIDSTWNDN
NEYEVWDGEARCHGFGHEIAIKHIRPVMPLLMMRASLEAQQRFAPQKRPYLISRSGCAGM
QRYVQTWSGDNRTNWETLRYNTRMGLGMSLSGLFNVGHDVGGFSGDKPDPELFVRWVQNG
VMHPRFTIHSWNDDQTVNEAWMYPEVTPAIRSAIELRYRLLPYLYTLLWQAHADDEPMLR
PTFLDHEHDAQTFAECDDFLLGRDLLVASVVEPGARQRRVWLPANQDGWYDFYSHQWYAG
GQWIVLDAPLEKLPLLVRAGAGLPLSERIRHVCAEKDDTRELKLFPLKGMGTCRGLLFED
DGESWGYRNGNALWVEWEMVCDSASINLKVKARGDYRPAWKALKVSLPAGEKRRLRVNGE
KRSEWRV