Protein Info for BWI76_RS08285 in Klebsiella michiganensis M5al

Annotation: replication initiation regulator SeqA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 182 PF17206: SeqA_N" amino acids 1 to 36 (36 residues), 81.4 bits, see alignment 2.2e-27 PF03925: SeqA" amino acids 72 to 180 (109 residues), 163.3 bits, see alignment E=1.9e-52

Best Hits

Swiss-Prot: 86% identical to SEQA_SALTY: Negative modulator of initiation of replication (seqA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03645, negative modulator of initiation of replication (inferred from 92% identity to kva:Kvar_3661)

Predicted SEED Role

"SeqA protein, negative modulator of initiation of replication"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B0P9 at UniProt or InterPro

Protein Sequence (182 amino acids)

>BWI76_RS08285 replication initiation regulator SeqA (Klebsiella michiganensis M5al)
MKTIEVDDELYSYIASHTKHIGESASDILRRMLKFSAVSQPVAPVAKAAPAPAPTPVAEV
KPANPLKDKVRAMRELLLSDEYADQKRAVNRFMLVLTTLYSLDSKAFAEATESLHGRTRV
YFAEDERTLQKNGNQTKPKQVPGTPWWVITNTNTGRKCSMIEHIMQSMQFPAELIEKVCG
TI