Protein Info for BWI76_RS07905 in Klebsiella michiganensis M5al

Annotation: trimethylamine-N-oxide reductase (cytochrome c)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 769 PF18364: Molybdopterin_N" amino acids 11 to 47 (37 residues), 33.9 bits, see alignment 3.9e-12 PF00384: Molybdopterin" amino acids 52 to 508 (457 residues), 182.5 bits, see alignment E=1.9e-57 PF01568: Molydop_binding" amino acids 624 to 744 (121 residues), 91.9 bits, see alignment E=4.1e-30

Best Hits

KEGG orthology group: K07812, trimethylamine-N-oxide reductase (cytochrome c) 2 [EC: 1.7.2.3] (inferred from 92% identity to kva:Kvar_3725)

Predicted SEED Role

"Anaerobic dimethyl sulfoxide reductase chain A (EC 1.8.5.3)" (EC 1.8.5.3)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.8.5.3

Use Curated BLAST to search for 1.7.2.3 or 1.8.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B0W1 at UniProt or InterPro

Protein Sequence (769 amino acids)

>BWI76_RS07905 trimethylamine-N-oxide reductase (cytochrome c) (Klebsiella michiganensis M5al)
MKKQHNLTVMHWGTWQVQARDGNIEAVTPVPWDKNPSPIGQSLPDAVTSKTRIRRPAVRA
GYLQNGPASREGRGKEPFVEVSWEVALDLLARELNSVKARCGNEAIFGGSYGWASAGRFH
HAQSQLHRFLKCFGGYTASTNTYSSAAGERILPHILGPLSPLHRQHTHFSELARECQLFV
AFGGLPLRNAQVNGGGANDHMLKYWLEKMQEQGTRFINISPVRNDLSAVESAEWLAVRPG
TDTALLLALCYVLITESLYDSAFVASHTVGFAPYRAYLMGERDGVAKTPEWAAAITGIEA
QRIAALAREMASLRTMVNISWSIQRARQGEQAYWATVALTALLGQIGTPGGGLGFGYACT
NLAGAARKAFSGPRLPAGDNAVNSVIPVARLSDMLLHPGEAYEFDGQHLRYPDIRLVYWA
GGNAFHHHQDLNRLCEAWRRPETVVVHEQFWTAQAKFSDIVLPATTSLEREDIGSGGHDG
FMIAMSAQIPPVGEARDDYAIFCDLAERLGFAERFSEGRDAGQWLRQIYEASRPRAQEEG
IALPSFDAFWQQGVLEYSAPEKPQVFLADFRADPQRYPLATPSGKIELFSETIAGFGYRE
CPGHPWWDEQEAQRQRQEAARWPLHLLSSQPRTRLHSQYDHGSVSRATKIEGREPLWMHP
QDAQARDIREGSVVKVYNARGAILAGVHLSEQILPGVVQMSTGAWYDPLDPNEKGSLDKH
GNPNVLTEDRGSSRLGQGCSAQSCWVEIEPWREALPPVTAFDPPRFIGA