Protein Info for BWI76_RS07860 in Klebsiella michiganensis M5al

Annotation: cytosine permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 420 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 51 to 75 (25 residues), see Phobius details amino acids 96 to 125 (30 residues), see Phobius details amino acids 131 to 150 (20 residues), see Phobius details amino acids 159 to 176 (18 residues), see Phobius details amino acids 195 to 215 (21 residues), see Phobius details amino acids 228 to 255 (28 residues), see Phobius details amino acids 261 to 282 (22 residues), see Phobius details amino acids 305 to 323 (19 residues), see Phobius details amino acids 329 to 351 (23 residues), see Phobius details amino acids 366 to 384 (19 residues), see Phobius details amino acids 387 to 405 (19 residues), see Phobius details PF02133: Transp_cyt_pur" amino acids 24 to 385 (362 residues), 56.5 bits, see alignment E=1.2e-19

Best Hits

KEGG orthology group: K10974, cytosine permease (inferred from 92% identity to kpe:KPK_3942)

Predicted SEED Role

"Cytosine/purine/uracil/thiamine/allantoin permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B0V0 at UniProt or InterPro

Protein Sequence (420 amino acids)

>BWI76_RS07860 cytosine permease (Klebsiella michiganensis M5al)
MSNSNDFPLVEAPASGRKGVFSISMVLFSFTFFTGTMFAGGKLGVSFSIVNLLWIAVIGN
FLLALYAASLGWIAARSGLNTVLMGRFCFGEIGSKLADFILGFAELGWYAWGTATVAISL
VKILALPEATTIPLMILFGILFCVTALVGYKGLDALSRVSVPLMFILLVVSMYLAAHHAG
GWQAMTQIEPGETMTWSAAITMVFGTFASGATQATNWTRLANSSRTAIVASMSSFLIGNG
LMIIAGAWCAIVYQQADIVEVLILQGLSVAAVVMLCLNLLTIQGPTIYNVSAAACHLLRS
ERRRTLTVVAAGVGILLAIGGMYEMLIPFLVLLGSIIPPIGGVILADYWFYRGGRYPLLH
TARLPRFNWLGLGAYAVGAVVAYLSPWIAPLVGISVSALAYIALTRLSKRQPAADSVAEQ