Protein Info for BWI76_RS07610 in Klebsiella michiganensis M5al

Annotation: choline dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 554 PF00732: GMC_oxred_N" amino acids 3 to 300 (298 residues), 206 bits, see alignment E=6.7e-65 TIGR01810: choline dehydrogenase" amino acids 4 to 537 (534 residues), 990.2 bits, see alignment E=1.2e-302 PF05199: GMC_oxred_C" amino acids 393 to 527 (135 residues), 144.6 bits, see alignment E=3.2e-46

Best Hits

Swiss-Prot: 95% identical to BETA_KLEP3: Oxygen-dependent choline dehydrogenase (betA) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: None (inferred from 95% identity to eae:EAE_13515)

MetaCyc: 91% identical to choline dehydrogenase (Escherichia coli K-12 substr. MG1655)
Choline dehydrogenase. [EC: 1.1.99.1]; 1.1.99.1 [EC: 1.1.99.1]; RXN0-7231 [EC: 1.1.99.1]

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B0D5 at UniProt or InterPro

Protein Sequence (554 amino acids)

>BWI76_RS07610 choline dehydrogenase (Klebsiella michiganensis M5al)
MQFDYIIIGAGSAGNVLATRLTEDPDTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGRRY
NWAYETEPEPHMNHRRMECGRGKGLGGSSLINGMCYIRGNAMDLDNWASAPGLEHWSYLD
CLPYYRKAETRDIGANDYHGGDGPVSVTTPKQGNNPLFHAMIEAGVQAGYPRTDDLNGYQ
QEGFGPMDRTVTPQGRRASTARGYLDQARARPNLTIRTHALTDHIIFAGKRAVGVEWLEG
DSTAPSKATANKEVLLCAGAIASPQILQRSGVGSPELLRQFDISLVHALPGVGENLQDHL
EMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGIGASNQFEAGGFIRSREAFAWPNI
QYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRLKSRDPHQHPAILFNYMSHEQD
WQEFRDAIRITREIMSQPALDNYRGREISPGIECQSDAELDEFVRNHAETAFHPCGTCKM
GYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADAIRGRQPLPKS
TAAYYVANGAPVRR