Protein Info for BWI76_RS07505 in Klebsiella michiganensis M5al

Annotation: hydrophobe/amphiphile efflux-1 family RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1030 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 341 to 360 (20 residues), see Phobius details amino acids 367 to 388 (22 residues), see Phobius details amino acids 394 to 417 (24 residues), see Phobius details amino acids 438 to 459 (22 residues), see Phobius details amino acids 471 to 497 (27 residues), see Phobius details amino acids 534 to 553 (20 residues), see Phobius details amino acids 864 to 881 (18 residues), see Phobius details amino acids 890 to 910 (21 residues), see Phobius details amino acids 916 to 940 (25 residues), see Phobius details amino acids 964 to 985 (22 residues), see Phobius details amino acids 996 to 1019 (24 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1022 (1022 residues), 1080.6 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1020 (1020 residues), 1039.6 bits, see alignment E=0 PF03176: MMPL" amino acids 334 to 508 (175 residues), 30.4 bits, see alignment E=2e-11 amino acids 815 to 1023 (209 residues), 28.1 bits, see alignment E=9.8e-11

Best Hits

KEGG orthology group: None (inferred from 91% identity to kpe:KPK_4024)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B0H0 at UniProt or InterPro

Protein Sequence (1030 amino acids)

>BWI76_RS07505 hydrophobe/amphiphile efflux-1 family RND transporter (Klebsiella michiganensis M5al)
MLTFFIRRPRFAMVIALLMTFVGAVSLKLIPVEQYPQITPPVINVSASWPGASAADVAEA
IAAPLETQLNGVDHMLYMESTSSDEGTYSLSLTFAAGTDADLAAIDVQNRVSQAVAQLPA
DVQQNGVQVRKRATNLLMGVSLYSPLGTLSPLFVSNYASTQVREALARLPGVGEVQIFGA
RDYSMRIWLRPDRMNALNITTDDVSQALREQNVQGAAGQVGTPPVFNGQQQTLTINGIGR
LSDAAGFGQIVVRSGDRGQLVRLSDVATIELGARSYSSGAQLNGKDSAYLGIYPTPTANA
LQVASAVRAELTRLHARFPADLTWEVKFDTTRFVAATIKEIGVSLALTLLAVVVVVSLFL
QSWRATLIVALAIPVSLIGTFAVLYALGYSANTLSLFAIILALTMVVDDAIVVVESVESK
MAEGLARGAATAEALRQIAGPVIATTLVLLAVFVPVAMLPGIVGELYRQFAVTLSTAVTL
SSVVALTLTPALCALLLRSRPQQPAAIWRGFNRGLDTVRDGYGRLVGRMNRRPWLALAAT
TAAAGVVVFSFTTMPKGFLPQEDQGYFFASVQLPEAASLERTEAVMAQARELLKLNPAVE
DVIQVSGFNILNGTSASNGGFISVMLKDWHQRPPLEAVMEKVQGQLMGLPEATIMTFAPP
TLPGLGNASGFNLRILAQAGQSPAELEQVTQQVLRTANQYPQLSRVFTTWSSNVPQLTLT
VDRDQAARLNVPVARIFSSLQTAFGGTRAGDFSINNRVYHVVMQNEMQWRERAEQISELY
VRSDSGERVRLSNLVTITPTVGAPFIQQYNQFPSVSVSGSATEGVSSRTAMAVMEQILQA
NLPHGYDYAWSGISWQEQQTGNQAVWIVLAAVAMAWLFLVAQYESWTLPASVMLSVLFAI
GGSLLWLWWAGYANDVYVQIGLVLLIALAAKNAILIVEFARAKREEGMSIVDAAREGATR
RFRAVMMTAVSFIIGIVPMMLATGAGAQSRRIIGTTVFSGMLVATVIGILFIPSLYVLFQ
RLREWGHRRM