Protein Info for BWI76_RS07045 in Klebsiella michiganensis M5al

Annotation: acyl-CoA synthetase FdrA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 555 PF02629: CoA_binding" amino acids 193 to 287 (95 residues), 39.8 bits, see alignment E=6.3e-14 PF00549: Ligase_CoA" amino acids 336 to 491 (156 residues), 103.5 bits, see alignment E=9.1e-34

Best Hits

Swiss-Prot: 76% identical to FDRA_ECOLI: Protein FdrA (fdrA) from Escherichia coli (strain K12)

KEGG orthology group: K02381, FdrA protein (inferred from 90% identity to kpu:KP1_1375)

Predicted SEED Role

"Protein fdrA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B016 at UniProt or InterPro

Protein Sequence (555 amino acids)

>BWI76_RS07045 acyl-CoA synthetase FdrA (Klebsiella michiganensis M5al)
MIHAFIKKGCFQDSVSLMIISRKLSESENVDDVSVMMGTPANKSLLETTGFWHDDFTTAT
PNDICVAIRADGADASVAEMINARLDEALAALAQGSGQSQSLSVVRRWQSATQKLPQANM
ALISVAGEYAAELAQQALSSEKNVMIFSDNVTLEDEIALKTRARDKGLLVMGPDCGTAMI
AGTPLAFANVTPDGNIGVIGASGTGIQELVSQIVLGGEGISHAIGLGGRDLSAEVGGISA
QTALEMLTQDGQSQVLAFVSKPPAEAVRQKVISAMKRSAKPVVALFLGYAPPAARDENVW
FARTLDEAGRLACLLARVARYQQTLSAVAGKQIRGLYTGGTLAAESAGLLAERLNITPDA
HHPQGMMLNAQGHQVVDLGDDFYTVGRPHPMIDPSLRNQLIAELGEENQVGVLLLDVVIG
YGATADPAESLVEACLRAWAVRDERHPLHIIATVTGTESDPQCRSRQIASLEDAGIVVVD
SLPEATLLASALISPQRMAELAPRASLLDGVAVINAGLRSFALDLQSAGTPVVHYQWAPI
AGGNKKLARLLERLQ