Protein Info for BWI76_RS07035 in Klebsiella michiganensis M5al
Annotation: Zn-dependent hydrolase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 81% identical to ALLC_ECOLI: Allantoate amidohydrolase (allC) from Escherichia coli (strain K12)
KEGG orthology group: K02083, allantoate deiminase [EC: 3.5.3.9] (inferred from 94% identity to kpu:KP1_1372)MetaCyc: 81% identical to allantoate amidohydrolase (Escherichia coli K-12 substr. MG1655)
Allantoate deiminase. [EC: 3.5.3.9]
Predicted SEED Role
"Allantoate amidohydrolase (EC 3.5.3.9)" in subsystem Allantoin Utilization (EC 3.5.3.9)
MetaCyc Pathways
- allantoin degradation IV (anaerobic) (8/9 steps found)
- allantoin degradation to glyoxylate II (5/5 steps found)
- allantoin degradation to glyoxylate III (5/5 steps found)
- superpathway of allantoin degradation in plants (7/8 steps found)
- allantoin degradation to ureidoglycolate II (ammonia producing) (4/4 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 3.5.3.9
Use Curated BLAST to search for 3.5.3.9
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285AZW0 at UniProt or InterPro
Protein Sequence (411 amino acids)
>BWI76_RS07035 Zn-dependent hydrolase (Klebsiella michiganensis M5al) MAHYFRQAIEETLPWLSSFGADPTGGITRLLYSPEWLQAQQAFKQRMSESGLETRFDEVG NLYGRLPGTRFPDEVILSGSHIDSVVNGGNLDGQFGALAAWLAVRWLKETYGAPLRTVEV LALAEEEGSRFPYVFWGSKNIVGIANPADVREINDAKGVAFVDAMKQCGFTLPAAPLAPR RDIKAFVELHIEQGRVLETNKQSIGVVNAIVGQRRYTVTLTGESNHAGTTPMGYRRDTVH AFSRICCESIAKAKAHGDPLVLTFGKVDPQPNTVNVVPGKTVFTMDCRHTDARELTAFTE VIEADMRRICREMEIGIEIDLWMDEAPVLMDKTLVARLTALCEKERVNFRVMHSGAGHDA QIFAPCFPTCMIFMPSIKGISHNPAESTHIDDLAEGVKTLALMLHQLAWTE