Protein Info for BWI76_RS06995 in Klebsiella michiganensis M5al

Annotation: hydroxypyruvate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03234: hydroxypyruvate isomerase
  • amino acids 3 to 255 (253 residues), 405.3 bits, E=4.5e-126
• PF01261: AP_endonuc_2
  • amino acids 21 to 256 (236 residues), 175 bits, E=1.2e-55

Best Hits

Swiss-Prot: 77% identical to HYI_ECOLI: Hydroxypyruvate isomerase (hyi) from Escherichia coli (strain K12)

KEGG orthology group: K01816, hydroxypyruvate isomerase [EC: 5.3.1.22] (inferred from 95% identity to kpu:KP1_1362)

MetaCyc: 77% identical to hydroxypyruvate isomerase (Escherichia coli K-12 substr. MG1655)
Hydroxypyruvate isomerase. [EC: 5.3.1.22]

Predicted SEED Role

"Hydroxypyruvate isomerase (EC 5.3.1.22)" (EC 5.3.1.22)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.3.1.22

Use Curated BLAST to search for 5.3.1.22

Sequence Analysis Tools

See A0A285B006 at UniProt or InterPro

Protein Sequence (258 amino acids)

>BWI76_RS06995 hydroxypyruvate isomerase (Klebsiella michiganensis M5al)
MLRFSANLSMLFQEYDFLERFDKAAACGFRAVEFMFPYDYAPEVLKQKLSDNRLEHTLHN
LPAGDWAAGERGIACIPGREAEFREGVDAAVRYAKALGNRKINCLVGKTPVGYREDHIRA
TLVANLRFAAAALAQEGILLLIEPINYFDMPGFYLNTTHQALALIDEVGSDNLKIQYDIY
HMQRMEGELTHTMQTYANRIGHLQIADNPERGEPGTGEINYDYLFKFIDKSNYDGWVGCE
YKPLTTTEAGLTWFNRYR