Protein Info for BWI76_RS06985 in Klebsiella michiganensis M5al

Annotation: transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 272 PF09339: HTH_IclR" amino acids 23 to 73 (51 residues), 46.6 bits, see alignment 2.4e-16 PF01614: IclR" amino acids 141 to 263 (123 residues), 130.8 bits, see alignment E=3e-42

Best Hits

Swiss-Prot: 98% identical to ALLR_KLEPN: HTH-type transcriptional repressor AllR (allR) from Klebsiella pneumoniae

KEGG orthology group: K10973, IclR family transcriptional regulator, negative regulator of allantoin and glyoxylate utilization operons (inferred from 98% identity to kpu:KP1_1360)

Predicted SEED Role

"Negative regulator of allantoin and glyoxylate utilization operons" in subsystem Allantoin Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZU7 at UniProt or InterPro

Protein Sequence (272 amino acids)

>BWI76_RS06985 transcriptional regulator (Klebsiella michiganensis M5al)
MTEVRRRGRPGQQEPSAQKGAQALERGIAILQYLEKSGGSSSISDISLNLDLPLSTTFRL
LKVLEGADFVYQDAQLGWWHIGLGAFNIGSAYIHNRDVLSVGGPFMRRLMLMSGETVNVA
IRNGNEAVLIGQQECKSMVRMCAPLGSRLPLHASGAGKALLYPLSAEELVDVIVKTGLQR
FTPATIVDLPVLQRNLDEARACGYSIDQEEHVTGLNCIASAVYDDVGSVVAAISISGPAS
RLTPDRFISQGELVRETARNISTALGLKPQAD