Protein Info for BWI76_RS06975 in Klebsiella michiganensis M5al

Annotation: DNA-binding transcriptional activator AllS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 307 PF00126: HTH_1" amino acids 6 to 62 (57 residues), 73.8 bits, see alignment E=8.8e-25 PF03466: LysR_substrate" amino acids 90 to 287 (198 residues), 92.9 bits, see alignment E=1.9e-30

Best Hits

Swiss-Prot: 92% identical to ALLS_KLEPN: HTH-type transcriptional activator AllS (allS) from Klebsiella pneumoniae

KEGG orthology group: K10972, LysR family transcriptional regulator, transcriptional activator of the allD operon (inferred from 94% identity to kpu:KP1_1357)

Predicted SEED Role

"DNA-binding transcriptional activator of the allD operon" in subsystem Allantoin Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZZ6 at UniProt or InterPro

Protein Sequence (307 amino acids)

>BWI76_RS06975 DNA-binding transcriptional activator AllS (Klebsiella michiganensis M5al)
MLDPETLRTFVSVAESGSFSRAAEKLYKTTATISYRIKLLEDNTGVALFSRTTRSVLLTP
AGMHLLAQAREWLGWIDSMPGELQQINDGVERQVNIVVNNLMYDPQAIARLLAWLSQRYP
FTQFHFSRQIYMGVWDTLLHDDFSLAIGVTGTEPLGENIAVTPLGEVSWLFVMSPHHPLG
QQSDPLSEAQLRRYPAVNIEDSARRLTKRVAWRLPGQKEIVVPDIETKIAAHIAGVGIGF
LPEPLCQPLIARGELIARQIPAMRPPSPLSLAWRKDHHGKAVQDIASLFVHSAPEIQGFL
TLFSDTP