Protein Info for BWI76_RS06835 in Klebsiella michiganensis M5al

Annotation: molecular chaperone HtpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 624 PF02518: HATPase_c" amino acids 28 to 182 (155 residues), 34.1 bits, see alignment E=5e-12 PF13589: HATPase_c_3" amino acids 29 to 167 (139 residues), 41.8 bits, see alignment E=1.6e-14 PF00183: HSP90" amino acids 218 to 623 (406 residues), 428.9 bits, see alignment E=5.5e-132

Best Hits

Swiss-Prot: 96% identical to HTPG_KLEP7: Chaperone protein HtpG (htpG) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: None (inferred from 96% identity to eae:EAE_13005)

MetaCyc: 91% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B023 at UniProt or InterPro

Protein Sequence (624 amino acids)

>BWI76_RS06835 molecular chaperone HtpG (Klebsiella michiganensis M5al)
MKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSQPDLYEGD
GELRVRVSFDKDNRTLTIADNGIGMNRDEVIDHLGTIAKSGTKAFLESMGSDQAKDSQLI
GQFGVGFYSAFIVADKVTVRTRAAGDSAENGVFWESAGEGEYTVADINKADRGTEITLHL
REGEDDFLNDWRVRSIISKYSDHIALPVEIEKREEVDGETVISWEKINKAQALWTRNKSE
IKDDEYNEFYKHIAHDYSDPLTWSHNRVEGKQEYTSLLYIPSQAPWDMWNRDHKHGLKLY
VQRVFIMDDAEQFMPNYLRFVRGLVDSNDLPLNVSREILQDSSVTRNLRTALSKRALQML
EKLAKDDAEKYQTFWQQFGLVLKEGPAEDQANQQAIAKLLRFASTHTDSAAQTVSLEEYV
SRMKEGQEKIYYITADSYAAAKSSPHLELLRKKGIEVLLLSDRIDEWMMSYLTEFDGKPF
QSVAKADESLDKLTDEVDETTKEAEKALEPFVERAKTLLGDRVKEVRLTHRLTDTPAIVT
TDADEMSTQMAKLFAAAGQAAPEVKYIFELNPLHPLVKRAADTQDDAQFGEWVELLLDQA
LLAERGTLEDPNQFIRRMNQLLAS