Protein Info for BWI76_RS06465 in Klebsiella michiganensis M5al

Annotation: IclR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 252 PF09339: HTH_IclR" amino acids 14 to 64 (51 residues), 38.4 bits, see alignment 8.4e-14 PF01614: IclR" amino acids 130 to 235 (106 residues), 82 bits, see alignment E=3.6e-27

Best Hits

KEGG orthology group: K02624, IclR family transcriptional regulator, pca regulon regulatory protein (inferred from 91% identity to kva:Kvar_3993)

Predicted SEED Role

"Transcriptional regulator, IclR family" in subsystem Homogentisate pathway of aromatic compound degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZI5 at UniProt or InterPro

Protein Sequence (252 amino acids)

>BWI76_RS06465 IclR family transcriptional regulator (Klebsiella michiganensis M5al)
MQNQIHPRDLIVGLQKGLALIQLFSKEHPRLTVPQAAKMSGLTQSAARRFFLTLLHERYL
QTDGRYYWLTPKALRLGQAYVDSAQFPRMVRPIVEYIASRTEEHASVGVIDDDELVYIAR
SKHTPFNSTSVRLGERVPIYCTAGGRLWLASLAEAECETVLQRIKREQRTPYTVTDVTAL
MEKIAQVRRQGYAAIEQEFEIGMLVLAVPLSDREGIYWGALSLTSHQSRTSIEALCREHL
DLLYSAQAMLVG