Protein Info for BWI76_RS06435 in Klebsiella michiganensis M5al

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 transmembrane" amino acids 24 to 47 (24 residues), see Phobius details amino acids 61 to 80 (20 residues), see Phobius details amino acids 91 to 110 (20 residues), see Phobius details amino acids 116 to 137 (22 residues), see Phobius details amino acids 148 to 171 (24 residues), see Phobius details amino acids 178 to 200 (23 residues), see Phobius details amino acids 256 to 279 (24 residues), see Phobius details amino acids 293 to 314 (22 residues), see Phobius details amino acids 326 to 354 (29 residues), see Phobius details amino acids 388 to 407 (20 residues), see Phobius details amino acids 414 to 435 (22 residues), see Phobius details PF07690: MFS_1" amino acids 30 to 289 (260 residues), 125.7 bits, see alignment E=3.1e-40 amino acids 261 to 446 (186 residues), 82 bits, see alignment E=6.2e-27 PF00083: Sugar_tr" amino acids 34 to 275 (242 residues), 93.2 bits, see alignment E=2.6e-30 PF06779: MFS_4" amino acids 46 to 202 (157 residues), 38.2 bits, see alignment E=1.7e-13

Best Hits

Swiss-Prot: 51% identical to PCAK_PSEAE: 4-hydroxybenzoate transporter PcaK (pcaK) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K08195, MFS transporter, AAHS family, 4-hydroxybenzoate transporter (inferred from 87% identity to kpn:KPN_00382)

Predicted SEED Role

"4-hydroxybenzoate transporter" in subsystem Cinnamic Acid Degradation or Gentisare degradation or Phenylpropanoid compound degradation or Salicylate and gentisate catabolism or p-Hydroxybenzoate degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZL4 at UniProt or InterPro

Protein Sequence (454 amino acids)

>BWI76_RS06435 MFS transporter (Klebsiella michiganensis M5al)
MTQTQRLDVRELINANPLSRFQKLVVLLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHE
LGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRF
LTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSL
MLLGGILPLLFAPVLIWLLPESVRFLVVKRAPAERIRRILQRLYPGQIPDEAEFSLPTQP
VQANAMRIVLSRQYRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVSQAAVMTAMY
QAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAASFALICLLAFISGACLN
GANTGMNALSARYYPTEARATGSSWMHGVGRLGAILSAFAGAEMLALNISFESVFLILGI
PAAITVAGLAAKGVFAADPEPKPTASTAPVRSTF