Protein Info for BWI76_RS06310 in Klebsiella michiganensis M5al

Annotation: protein translocase subunit SecD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 615 transmembrane" amino acids 7 to 26 (20 residues), see Phobius details amino acids 453 to 471 (19 residues), see Phobius details amino acids 477 to 498 (22 residues), see Phobius details amino acids 504 to 524 (21 residues), see Phobius details amino acids 548 to 571 (24 residues), see Phobius details amino acids 577 to 605 (29 residues), see Phobius details PF13721: SecD-TM1" amino acids 2 to 103 (102 residues), 125.8 bits, see alignment E=2.2e-40 PF07549: Sec_GG" amino acids 120 to 140 (21 residues), 25.2 bits, see alignment (E = 2.2e-09) TIGR01129: protein-export membrane protein SecD" amino acids 123 to 601 (479 residues), 500 bits, see alignment E=5.6e-154 PF21760: SecD_1st" amino acids 227 to 285 (59 residues), 102.5 bits, see alignment 1.6e-33 TIGR00916: protein-export membrane protein, SecD/SecF family" amino acids 345 to 594 (250 residues), 278.2 bits, see alignment E=5.5e-87 PF02355: SecD_SecF" amino acids 433 to 601 (169 residues), 53.1 bits, see alignment E=6.8e-18 PF03176: MMPL" amino acids 487 to 600 (114 residues), 33.7 bits, see alignment E=5.1e-12

Best Hits

Swiss-Prot: 92% identical to SECD_SHIFL: Protein translocase subunit SecD (secD) from Shigella flexneri

KEGG orthology group: K03072, preprotein translocase subunit SecD (inferred from 92% identity to eco:b0408)

MetaCyc: 92% identical to Sec translocon accessory complex subunit SecD (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Protein-export membrane protein SecD (TC 3.A.5.1.1)" (TC 3.A.5.1.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZI7 at UniProt or InterPro

Protein Sequence (615 amino acids)

>BWI76_RS06310 protein translocase subunit SecD (Klebsiella michiganensis M5al)
MLNRYPLWKYVMLVVVIVVGLVYALPNLYGEDPAVQITGARGVAASEQTLIQVQKTLQEE
KITAKSVALEEGAILARFDTTDIQLRAREALMGVLGDKYVVALNLAPATPRWLAALYAEP
MKLGLDLRGGVHFLMEVDMDTALGKLQEQNIDSLRSELRDKGIPYTTVRKEDNYGLSIAF
RDSAARDQAISYLSPRHRDLVISTQGSTGLKAVMTDDRLKEAREYAVQQNITILRNRVNQ
LGVAEPLVQRQGADRIVVELPGIQDTARAKEILGATATLEFRLVNTNVDSSAAASGRVPG
DSEVKFTREGQPVVLYKRVILTGDHITDSTSSMDEYNQAQVNISLDSAGGNIMSNFTKDN
IGKPMATLFVEYKDSGKKDANGRAILAKEEEVINIANIQSRLGNSFRITGISNATEARQL
SLLLRAGALIAPIQIVEERTIGPTLGMQNIKQGLEACLAGLVVSILFMIFFYKKFGLIAT
SALVANLVLIVGIMSLIPGATLTMPGIAGIVLTLAVAVDANVLINERIKEELSNGRSVQQ
AIDEGYRGAFSSIFDANITTLIKVIILYAVGTGAIKGFAITTGIGIATSMFTAIVGTRAI
VNLLYGGKRVKKLSI