Protein Info for BWI76_RS06065 in Klebsiella michiganensis M5al

Annotation: taurine ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 320 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF13379: NMT1_2" amino acids 21 to 233 (213 residues), 71 bits, see alignment E=2.8e-23 PF04069: OpuAC" amino acids 24 to 248 (225 residues), 98.3 bits, see alignment E=1.2e-31 TIGR01729: taurine ABC transporter, periplasmic binding protein" amino acids 25 to 320 (296 residues), 502.8 bits, see alignment E=1.8e-155 PF12974: Phosphonate-bd" amino acids 44 to 217 (174 residues), 31.9 bits, see alignment E=2e-11 PF09084: NMT1" amino acids 48 to 241 (194 residues), 63.8 bits, see alignment E=4.6e-21

Best Hits

Swiss-Prot: 90% identical to TAUA_ECOLI: Taurine-binding periplasmic protein (tauA) from Escherichia coli (strain K12)

KEGG orthology group: K02051, sulfonate/nitrate/taurine transport system substrate-binding protein (inferred from 92% identity to kpe:KPK_4377)

MetaCyc: 90% identical to taurine ABC transporter periplasmic binding protein (Escherichia coli K-12 substr. MG1655)
ABC-64-RXN [EC: 7.6.2.7]

Predicted SEED Role

"Taurine-binding periplasmic protein TauA" in subsystem Taurine Utilization

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZD2 at UniProt or InterPro

Protein Sequence (320 amino acids)

>BWI76_RS06065 taurine ABC transporter substrate-binding protein (Klebsiella michiganensis M5al)
MALSSRITLIAALALAAFQAQAVNVTVAYQTSAEPAKVAQADNTFAKASGATVDWRKFDS
GASIVRALASGDVQIGNLGSSPLAVAATQQVPIEVFLLASKLGNSEALVVKKSITKPQDL
IGKRIAVPFISTTHYSLLSALKHWGIKPGQVQILNLQPPAIIAAWQRGDIDGAYVWAPAV
NALEKEGTVLTDSSQVGEWGAPTLDVWVVRKDFAEKHPDIVKAFAKSAIDAQQPYIANPD
EWLKQPENISKLARLSGVPEADVPGLVKGNTYLTAAQQAQELNGPVNKAIIDTAKFLKEQ
GKVPAAGSDYSQYVTDRFVK