Protein Info for BWI76_RS06060 in Klebsiella michiganensis M5al

Annotation: DNA-binding response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 209 PF00072: Response_reg" amino acids 4 to 116 (113 residues), 94.9 bits, see alignment E=5.3e-31 PF00196: GerE" amino acids 145 to 200 (56 residues), 68.7 bits, see alignment E=3.8e-23

Best Hits

Swiss-Prot: 49% identical to UHPA_SALTY: Transcriptional regulatory protein UhpA (uhpA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K07686, two-component system, NarL family, uhpT operon response regulator UhpA (inferred from 94% identity to cko:CKO_02815)

Predicted SEED Role

"Transcriptional regulatory protein UhpA" in subsystem Hexose Phosphate Uptake System

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZ91 at UniProt or InterPro

Protein Sequence (209 amino acids)

>BWI76_RS06060 DNA-binding response regulator (Klebsiella michiganensis M5al)
MIRVVLVDDHVVVRSGFAQLLSLEEDLEVVGQFSSSAQAWPALLRDDVDVAVMDIAMPDE
NGLSLLKRLRAQKPQFRAIILSIYDTPTFVQSALDAGASGYLTKRCGPEELVQAVRSVGM
GGHYLCADALRALRGGEQPAQVLEVLTPREREVFDLLVKGDSVKEIAFKLELSHKTVHVH
RANVLGKLQCHSTIDLVHFALDHQLLAGH