Protein Info for BWI76_RS06005 in Klebsiella michiganensis M5al

Annotation: ethanolamine ammonia lyase large subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 462 PF06751: EutB" amino acids 11 to 444 (434 residues), 742.5 bits, see alignment E=7.5e-228

Best Hits

Swiss-Prot: 50% identical to EUTB_ECO57: Ethanolamine ammonia-lyase heavy chain (eutB) from Escherichia coli O157:H7

KEGG orthology group: K03735, ethanolamine ammonia-lyase large subunit [EC: 4.3.1.7] (inferred from 95% identity to kva:Kvar_4075)

MetaCyc: 50% identical to ethanolamine ammonia-lyase subunit alpha (Escherichia coli K-12 substr. MG1655)
Ethanolamine ammonia-lyase. [EC: 4.3.1.7]

Predicted SEED Role

"Ethanolamine ammonia-lyase heavy chain (EC 4.3.1.7)" in subsystem Ethanolamine utilization (EC 4.3.1.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.3.1.7

Use Curated BLAST to search for 4.3.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZG2 at UniProt or InterPro

Protein Sequence (462 amino acids)

>BWI76_RS06005 ethanolamine ammonia lyase large subunit (Klebsiella michiganensis M5al)
MYKTTLSGQVWRFDSLKTLMAKASPARSGDALAGVIAGSAEERMAAKMALAEVPLTEILD
NPLIPYEQDEVTRLILDTHDARGFAAIRHLTVGDFRDWLLDDATDEAALRQVARAITPEM
AAAVSKLMRNQDLILAASKCRVVTRFRNTIGLPGRLSVRLQPNHPTDDMKGIAASMLDGL
LYGAGDAVIGINPASDSLPVLAQLNHMLDDIIQRFAIPTQSCILTHVTNTLQLIERGAPV
DLVFQSVAGTEAANSGFGINLALLQEAREAALSLNRGTLGNNVMYFETGQGSCLSANAHH
GVDQQTCEARAYAVARHFEPLLVNTVVGFIGPEYLYDGKQIIRAGLEDHFCGKLMGLPIG
CDVCYTNHAEADQDDMDTLLTLLCAAGLTFLIGVPGADDIMLNYQSTSFHDALYARRLLG
LQHAPEFADWLTKMQIIDRHGALRLTDARHPLLSVLPQGEPV